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Yanan Guo
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NAFLD and NASH: etiology, targets and emerging therapies
10.1016/j.drudis.2024.103910 · 2024
Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030
10.1016/j.jhep.2018.05.036 · 2018
Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes
10.1002/hep.28431 · 2016
A multisociety Delphi consensus statement on new fatty liver disease nomenclature
10.1016/j.aohep.2023.101133 · 2024
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
10.1002/hep.20701 · 2005
Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity
10.1016/s0016-5085(99)70506-8 · 1999
Epidemiology of metabolic dysfunction-associated steatotic liver disease
10.3350/cmh.2024.0431 · 2025
Mechanisms and disease consequences of nonalcoholic fatty liver disease
10.1016/j.cell.2021.04.015 · 2021
Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease
10.1016/j.plipres.2012.10.004 · 2013
Sterol regulatory element-binding protein-1 (SREBP-1) is required to regulate glycogen synthesis and gluconeogenic gene expression in mouse liver
10.1074/jbc.m113.541110 · 2014
Regulation of AMPK activation by CD36 links fatty acid uptake to β-oxidation
10.2337/db14-0582 · 2015
ATF4-mediated CD36 upregulation contributes to palmitate-induced lipotoxicity in hepatocytes
10.1152/ajpgi.00163.2022 · 2023
Long-chain fatty acid activates hepatocytes through CD36 mediated oxidative stress
10.1186/s12944-018-0790-9 · 2018
PNPLA3 as a therapeutic target for fatty liver disease: the evidence to date
10.1080/14728222.2021.2018418 · 2021
A phase I/II study of ARO-HSD, an RNA interference therapeutic, for the treatment of non-alcoholic steatohepatitis
10.1016/j.jhep.2022.11.025 · 2023
A protein-truncating HSD17B13 variant and protection from chronic liver disease
10.1056/nejmoa1712191 · 2018
Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease
10.1038/ng.2901 · 2014
Resmetirom: first approval
10.1007/s40265-024-02045-0 · 2024
Randomized, controlled trial of the FGF21 analogue pegozafermin in NASH
10.1056/nejmoa2304286 · 2023
Effect of pemvidutide, a GLP-1/glucagon dual receptor agonist, on MASLD: a randomized, double-blind, placebo-controlled study
10.1016/j.jhep.2024.07.006 · 2025
Effect of empagliflozin on liver fat in patients with type 2 diabetes and nonalcoholic fatty liver disease: a randomized controlled trial (E-LIFT trial)
10.2337/dc18-0165 · 2018
Liver inflammation and fibrosis
10.1172/jci88881 · 2017
Triggering and resolution of inflammation in NASH
10.1038/s41575-018-0009-6 · 2018
Hepatic macrophage targeted siRNA lipid nanoparticles treat non-alcoholic steatohepatitis
10.1016/j.jconrel.2022.01.038 · 2022
Liver-targeted delivery of small interfering RNA of C–C chemokine receptor 2 with tetrahedral framework nucleic acid attenuates liver cirrhosis
10.1021/acsami.2c22579 · 2023
Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis
10.1126/scitranslmed.abe1692 · 2021
Cenicriviroc lacked efficacy to treat liver fibrosis in nonalcoholic steatohepatitis: AURORA phase III randomized Study
10.1016/j.cgh.2023.04.003 · 2024
Hepatocyte-specific CCAAT/enhancer binding protein α restricts liver fibrosis progression
10.1172/jci166731 · 2024
Targeting EFHD2 inhibits interferon-γ signaling and ameliorates non-alcoholic steatohepatitis
10.1016/j.jhep.2024.04.009 · 2024
Neutrophil extracellular traps activate hepatic stellate cells and monocytes via NLRP3 sensing in alcohol-induced acceleration of MASH fibrosis
10.1136/gutjnl-2023-331447 · 2024
Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)
10.1038/s41392-022-01119-3 · 2022
Hepatic stellate cells in liver fibrosis and siRNA-Based therapy
2016
Hepatocyte-targeted siTAZ therapy lowers liver fibrosis in NASH diet-fed chimeric mice with hepatocyte-humanized livers
10.1016/j.omtm.2023.101165 · 2023
The antifibrotic effects of TGF-β1 siRNA on hepatic fibrosis in rats
10.1016/j.bbrc.2011.05.023 · 2011
Nanoparticle-mediated RNA therapy attenuates nonalcoholic steatohepatitis and related fibrosis by targeting activated hepatic stellate cells
10.1021/acsnano.3c03217 · 2023
Retinol-binding protein-hijacking nanopolyplex delivering siRNA to cytoplasm of hepatic stellate cell for liver fibrosis alleviation
10.1016/j.biomaterials.2023.122134 · 2023
Unresolved referenced work
2024
Mechanisms of insulin action and insulin resistance
10.1152/physrev.00063.2017 · 2018
Hepatic insulin receptor: new views on the mechanisms of liver disease
10.1016/j.metabol.2023.155607 · 2023
Lipotoxicity and the gut-liver axis in NASH pathogenesis
10.1016/j.jhep.2017.11.014 · 2018
Suboptimal reliability of liver biopsy evaluation has implications for randomized clinical trials
10.1016/j.jhep.2020.06.025 · doi-reference
Challenges in the pharmaceutical development of lipid-based short interfering ribonucleic acid therapeutics
10.1517/17425247.2012.642363 · doi-reference
Antifibrotic therapy in nonalcoholic steatohepatitis: time for a human-centric approach
10.1038/s41575-023-00796-x · doi-reference
Anti-PEG antibodies: properties, formation, testing and role in adverse immune reactions to PEGylated nano-biopharmaceuticals
10.1016/j.addr.2020.07.024 · doi-reference
Considerations of the Japanese research working group for the ICH S6 & related issues regarding nonclinical safety assessments of oligonucleotide therapeutics: Comparison with those of biopharmaceuticals
10.1089/nat.2020.0879 · doi-reference
Image-based analysis of lipid nanoparticle-mediated siRNA delivery, intracellular trafficking and endosomal escape
10.1038/nbt.2612 · doi-reference
Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis
10.1038/s41467-022-35637-z · doi-reference
pPB peptide-mediated siRNA-Loaded stable nucleic acid lipid nanoparticles on targeting therapy of hepatic fibrosis
10.1021/acs.molpharmaceut.7b00709 · doi-reference
Antioxidative hyaluronic acid–bilirubin nanomedicine targeting activated hepatic stellate cells for anti-hepatic-fibrosis therapy
10.1021/acsnano.3c06107 · doi-reference
Lipid nanoparticle-mediated hepatocyte delivery of siRNA and silibinin in metabolic dysfunction-associated steatotic liver disease
10.1016/j.jconrel.2024.07.011 · doi-reference
Liposomal drug delivery systems: from concept to clinical applications
10.1016/j.addr.2012.09.037 · doi-reference
Knocking down barriers: advances in siRNA delivery
10.1038/nrd2742 · doi-reference
Special delivery: targeted therapy with small RNAs
10.1038/gt.2011.56 · doi-reference
Rubicon siRNA-encapsulated liver-targeting nanoliposome is a promising therapeutic for non-alcoholic fatty liver disease
10.1016/j.ijpharm.2025.125291 · doi-reference
Evaluation of the therapeutic potential effect of Fas receptor gene knockdown in experimental model of non-alcoholic steatohepatitis
10.1080/10715762.2019.1608982 · doi-reference
Targeting a novel inducible GPX4 alternative isoform to alleviate ferroptosis and treat metabolic-associated fatty liver disease
10.1016/j.apsb.2022.02.003 · doi-reference
BMS-986263 in patients with advanced hepatic fibrosis: 36-week results from a randomized, placebo-controlled phase 2 trial
10.1002/hep.32181 · doi-reference
Phase I randomized double-blind study of an RNA interference therapeutic targeting HSD17B13 for metabolic dysfunction-associated steatohepatitis
10.1016/j.jhep.2025.05.031 · doi-reference
Preclinical and clinical pharmacokinetics of JNJ-75220795, an siRNA therapeutic targeting PNPLA3, for Metabolic dysfunction-associated steatohepatitis
10.1002/jcph.6174 · doi-reference
Plozasiran (ARO-APOC3) for severe hypertriglyceridemia: the SHASTA-2 randomized clinical trial
10.1001/jamacardio.2024.0959 · doi-reference
CRISPR-Cas9 in vivo gene editing for transthyretin amyloidosis
10.1056/nejmoa2107454 · doi-reference
Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours
10.1038/s41416-020-0802-1 · doi-reference
AZD2693, a PNPLA3 antisense oligonucleotide, for the treatment of MASH in 148M homozygous participants: two randomized phase I trials
10.1016/j.jhep.2024.12.046 · doi-reference
Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
10.1038/nbt1081 · doi-reference
Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity
10.1038/s41467-018-02989-4 · doi-reference
Nucleoside modifications in RNA limit activation of 2'-5'-oligoadenylate synthetase and increase resistance to cleavage by RNase L
10.1093/nar/gkr586 · doi-reference
RNAi-based drug design: considerations and future directions
10.1038/s41573-024-00912-9 · doi-reference
RNA interference in the clinic: challenges and future directions
10.1038/nrc2966 · doi-reference
RNAi therapeutic and its innovative biotechnological evolution
10.1016/j.biotechadv.2019.04.012 · doi-reference
Phase 1 trials of PNPLA3 siRNA in I148M Homozygous Patients with MAFLD
10.1056/nejmc2402341 · doi-reference
Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: results from randomized phase III STELLAR trials
10.1016/j.jhep.2020.02.027 · doi-reference
Simtuzumab is ineffective for patients with bridging fibrosis or compensated cirrhosis caused by Nonalcoholic steatohepatitis
10.1053/j.gastro.2018.07.006 · doi-reference
Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial
10.1016/s0140-6736(19)33041-7 · doi-reference
FXR agonists for MASH therapy: lessons and perspectives from obeticholic acid
10.1002/med.21991 · doi-reference
Obeticholic acid impact on quality of life in patients with nonalcoholic steatohepatitis: REGENERATE 18-Month interim analysis
10.1016/j.cgh.2021.07.020 · doi-reference
Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
10.1016/s0140-6736(14)61933-4 · doi-reference
Long-term pioglitazone treatment for patients with Nonalcoholic steatohepatitis and prediabetes or type 2 diabetes mellitus: a randomized trial
10.7326/m15-1774 · doi-reference
Nonalcoholic steatohepatitis: the role of peroxisome proliferator-activated receptors
10.1038/s41575-020-00366-5 · doi-reference
Roles of the peroxisome proliferator-activated receptors (PPARs) in the pathogenesis of nonalcoholic fatty liver disease (NAFLD)
10.1016/j.phrs.2023.106786 · doi-reference
Phase 3 trial of semaglutide in metabolic dysfunction-associated steatohepatitis
10.1056/nejmoa2413258 · doi-reference