Redox-responsive MOF-based nano-inducer with cascade-enhanced multienzyme activities for synergistic tumor therapy

Tumor cells are under siege from all sides: tumor cell-mimic metal-organic framework nanoparticles triggering cuproptosis/ferroptosis/apoptosis for chemo-chemodynamic-photothermal-immunological synergistic antitumor therapy

10.1016/j.cej.2024.149640 · doi-reference

A carbon dot-doped Cu-MOF-based smart nanoplatform for enhanced immune checkpoint blockade therapy and synergistic multimodal cancer therapy

10.1039/d3tb00384a · doi-reference

A novel drug susceptibility testing AIEgen with spatiotemporal resolved progress-reporting characteristic for therapy of drug-resistant tumor

10.1016/j.mattod.2022.06.008 · doi-reference

A new strategy toward 'simple' water-soluble aie probes for hypoxia detection

10.1002/adfm.201903278 · doi-reference

Making aggregation-induced emission luminogen more valuable by gold: enhancing anticancer efficacy by suppressing thioredoxin reductase activity

10.1021/acsnano.1c02882 · doi-reference

Electron acceptor motif-manipulated NIR-II AIE photosensitizers synergically induce tumor pyroptosis through multimodal image-guided pure type I photodynamic and photothermal therapy

10.1016/j.biomaterials.2025.123490 · doi-reference

Biorthogonal guided activation of cGAS-STING by AIE photosensitizer nanoparticles for targeted tumor therapy and imaging

10.1002/adma.202305668 · doi-reference

Nanozyme as tumor energy homeostasis disruptor to augment cascade catalytic therapy

10.1021/acsnano.4c09982 · doi-reference

A self-driving and self-reporting petal-like Au-Cu2O metalloenzyme for probing H2S-mediated cuproptosis

10.1021/acsnano.6c01009 · doi-reference

Inflammatory microenvironment-responsive microsphere vehicles modulating gut microbiota and intestinal inflammation for intestinal stem cell niche remodeling in inflammatory bowel disease

10.1021/acsnano.4c17999 · doi-reference

MXene-based functional platforms for tumor therapy

10.1002/adma.202302559 · doi-reference

Biomimetic metal organic frameworks mediated by metformin and 1-MT for enhancing the synergistic treatment of photodynamic therapy, photothermal therapy and immunotherapy

10.1016/j.cej.2023.147932 · doi-reference

Microneedle-mediated transdermal delivery of cerium-iron bimetallic organic frameworks derivatives for melanoma therapy: enhanced peroxidase-like activity and adenosine triphosphate hydrolysis effect

10.1016/j.jcis.2026.139885 · doi-reference

Mn(III)-mediated carbon-centered radicals generate an enhanced immunotherapeutic effect

10.1039/d3sc03635a · doi-reference

Nano metal-photosensitizer based on Aza-BODIPY-Cu complex for CDT-enhanced dual phototherapy

10.1016/j.cclet.2023.109328 · doi-reference

A paramagnetic metal-organic framework enhances mild magnetic hyperthermia therapy by downregulating heat shock proteins and promoting ferroptosis via aggravation of two-way regulated redox dyshomeostasis

10.4028/b-wjqrp6 · doi-reference

Core-shell metal-organic frameworks with pH/GSH dual-responsiveness for combined chemo-chemodynamic therapy

10.1039/d2cc04218e · doi-reference

Core-shell inorganic NP@MOF nanostructures for targeted drug delivery and multimodal imaging-guided combination tumor treatment

10.1016/j.cis.2023.103007 · doi-reference

Intelligent theranostic systems enabled by aggregation-induced emission in precision medicine

10.1002/agt2.70156 · doi-reference

An NIR-II absorbing injectable hydrogel for boosted photo-immunotherapy toward human papillomavirus associated cancer

10.1002/agt2.743 · doi-reference

A calcium fluoride nanozyme for ultrasound-amplified and Ca2+-overload-enhanced catalytic tumor nanotherapy

10.1002/adma.202205680 · doi-reference

Nitrogen-centered lactate oxidase nanozyme for tumor lactate modulation and microenvironment remodeling

10.1021/jacs.3c02005 · doi-reference

Nanozymes for non-neoplastic diseases: catalytic therapy redefined

10.1002/agt2.70150 · doi-reference

Provoking tumor disulfidptosis by single-atom nanozyme via regulating cellular energy supply and reducing power

10.1038/s41467-025-60015-w · doi-reference

Tumor-penetrating nanoplatform with ultrasound "unlocking" for cascade synergistic therapy and visual feedback under hypoxia

10.1186/s12951-023-01765-x · doi-reference

A self-regulated phototheranostic nanosystem with single wavelength-triggered energy switching and oxygen supply for multimodal synergistic therapy of bacterial biofilm infections

10.1002/agt2.587 · doi-reference

Nanomaterials-driven in situ vaccination: a novel frontier in tumor immunotherapy

10.1186/s13045-025-01692-4 · doi-reference

Bioengineered hybrid dual-targeting nanoparticles reprogram the tumor microenvironment for deep glioblastoma photodynamic therapy

10.1038/s41467-025-63081-2 · doi-reference

Enhancing immunotherapy with tumor-responsive nanomaterials

10.1038/s41571-025-01000-6 · doi-reference

Tumor-microenvironment-activatable nanoparticle mediating immunogene therapy and M2 macrophage-targeted inhibitor for synergistic cancer immunotherapy

10.1021/acsnano.3c10037 · doi-reference

Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy

10.1186/s13045-024-01535-8 · doi-reference

Multicenter phase II trial of the WEE1 inhibitor adavosertib in refractory solid tumors harboring CCNE1 amplification

10.1200/jco.22.00830 · doi-reference

Targeted nanoparticle delivery unleashes synergistic photothermal and immunotherapeutic effects against hepatocellular carcinoma

10.1186/s12951-024-03030-1 · doi-reference

Gold-embedded yolk-shell mesoporous organosilica nanocomposite for microwave-enhanced targeted chemotherapy and immune modulation in hepatocellular carcinoma

10.1016/j.biomaterials.2025.123533 · doi-reference

Nanoparticle-mediated dual targeting of stromal and immune components to overcome fibrotic and immunosuppressive barriers in hepatocellular carcinoma

10.1016/j.jconrel.2025.113783 · doi-reference

Modulating lipid metabolism by nanoparticles (NPs)-mediated ACSL3 silencing to inhibit hepatocellular carcinoma growth and metastasis

10.1186/s12943-025-02274-1 · doi-reference