Abstract
No public abstract is available from the verified source records.
Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Privacy-aware community infrastructureGregory D Clemenson, Fred H Gage
Abstract
Authors
Institutions
No ROR-resolved institution is linked to this work yet.
Provenance
crossref
Confidence 100%
unpaywall
Confidence 95%
datacite
Confidence 0%
No local reference links have been materialized yet.
No local citing links have been materialized yet.
Neural consequences of environmental enrichment
10.1038/35044558 · 2000
More hippocampal neurons in adult mice living in an enriched environment
10.1038/386493a0 · 1997
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
10.1038/6368 · 1999
Running enhances neurogenesis, learning, and long-term potentiation in mice
10.1073/pnas.96.23.13427 · 1999
Running is the neurogenic and neurotrophic stimulus in environmental enrichment
10.1101/lm.2283011 · 2011
Aerobic exercise is the critical variable in an enriched environment that increases hippocampal neurogenesis and water maze learning in male C57BL/6J mice
10.1016/j.neuroscience.2012.06.007 · 2012
All about running: synaptic plasticity, growth factors and adult hippocampal neurogenesis
10.1007/7854_2012_220 · 2013
Exercise, energy intake, glucose homeostasis, and the brain,
10.1523/jneurosci.2814-14.2014 · 2014
Subpopulations of proliferating cells of the adult hippocampus respond differently to physiologic neurogenic stimuli
10.1002/cne.10945 · 2003
Differential 24h responsiveness of Prox1-expressing precursor cells in adult hippocampal neurogenesis to physical activity, environmental enrichment, and kainic acid-induced seizures
10.1016/j.neuroscience.2008.04.023 · 2008
Additive effects of physical exercise and environmental enrichment on adult hippocampal neurogenesis in mice
2009
Emergence of individuality in genetically identical mice
10.1126/science.1235294 · 2013
Short-term environmental enrichment, in the absence of exercise, improves memory, and increases NGF concentration early neuronal survival, and synaptogenesis in the dentate gyrus in a time-dependent manner
10.1002/hipo.22103 · 2013
Enrichment rescues contextual discrimination deficit associated with immediate shock
2014
Spine morphogenesis in newborn granule cells is differentially regulated in the outer and middle molecular layers
10.1002/cne.23581 · 2014
Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment
10.1002/ana.10262 · 2002
Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus
10.1038/nature02553 · 2004
Neuronal differentiation in the adult hippocampus recapitulates embryonic development
10.1523/jneurosci.3114-05.2005 · 2005
Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus
10.1523/jneurosci.3648-05.2006 · 2006
Computational influence of adult neurogenesis on memory encoding
10.1016/j.neuron.2008.11.026 · 2009
Experience-specific functional modification of the dentate gyrus through adult neurogenesis: a critical period during an immature stage
10.1523/jneurosci.4941-06.2007 · 2007
New neurons in an aged brain
10.1016/j.bbr.2011.10.009 · 2013
Environmental enrichment restores neurogenesis and rapid acquisition in aged rats
10.1016/j.neurobiolaging.2012.05.023 · 2013
Effects of environmental enrichment on gene expression in the brain
10.1073/pnas.97.23.12880 · 2000
Effects of enriched environment on gene expression and signal pathways in cortex of hippocampal CA1 specific NMDAR1 knockout mice
10.1016/j.brainresbull.2006.11.011 · 2007
Alteration of synaptic activity-regulating genes underlying functional improvement by long-term exposure to an enriched environment in the adult brain
10.1177/1545968313481277 · 2013
Gene expression profiling in the intact and injured brain following environmental enrichment
10.1093/jnen/63.6.598 · 2004
Opposing actions of environmental enrichment and Alzheimer's disease on the expression of hippocampal microRNAs in mouse models
10.1038/tp.2013.77 · 2013
Exercise, antidepressant treatment, and BDNF mRNA expression in the aging brain
10.1016/j.pbb.2003.10.020 · 2004
Exercise induces BDNF and synapsin I to specific hippocampal subfields
10.1002/jnr.20077 · 2004
Brain-derived neurotrophic factor (BDNF) is required for the enhancement of hippocampal neurogenesis following environmental enrichment
10.1111/j.1460-9568.2006.05059.x · 2006
Hippocampal epigenetic modification at the brain-derived neurotrophic factor gene induced by an enriched environment
10.1002/hipo.20775 · 2011
Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult rats
10.1016/j.expneurol.2004.11.016 · 2005
Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior
10.1073/pnas.0803702105 · 2008
TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment
10.1016/j.neuron.2008.06.023 · 2008
VEGF links hippocampal activity with neurogenesis, learning and memory
10.1038/ng1395 · 2004
Physical exercise leads to rapid adaptations in hippocampal vasculature: temporal dynamics and relationship to cell proliferation and neurogenesis
10.1002/hipo.20545 · 2009
Vascular niche for adult hippocampal neurogenesis
10.1002/1096-9861(20001002)425:4<479::aid-cne2>3.0.co;2-3 · 2000
Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo
10.1073/pnas.182296499 · 2002
VEGF is necessary for exercise-induced adult hippocampal neurogenesis
10.1111/j.1460-9568.2003.03041.x · 2003
Direct recordings of grid-like neuronal activity in human spatial navigation
10.1038/nn.3466 · doi-reference
Cellular networks underlying human spatial navigation
10.1038/nature01964 · doi-reference
Cellular mechanisms of spatial navigation in the medial entorhinal cortex
10.1038/nn.3340 · doi-reference
Intracellular dynamics of hippocampal place cells during virtual navigation
10.1038/nature08499 · doi-reference
Knowing where and getting there: a human navigation network
10.1126/science.280.5365.921 · doi-reference
Acquiring “the Knowledge” of London's layout drives structural brain changes
10.1016/j.cub.2011.11.018 · doi-reference
10.1073/pnas.070039597
10.1073/pnas.070039597 · doi-reference
A task to assess behavioral pattern separation (BPS) in humans: data from healthy aging and mild cognitive impairment
10.1016/j.neuropsychologia.2012.12.014 · doi-reference
Pattern separation in the human hippocampal CA3 and dentate gyrus
10.1126/science.1152882 · doi-reference
An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus
10.1073/pnas.0611721104 · doi-reference
Dynamics of hippocampal neurogenesis in adult humans
10.1016/j.cell.2013.05.002 · doi-reference
Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain
10.1126/science.1147851 · doi-reference
Neurogenesis in the adult human hippocampus
10.1038/3305 · doi-reference
Conditioned fear-induced opiate analgesia: a competing motivational state theory of stress analgesia
10.1111/j.1749-6632.1986.tb14617.x · doi-reference
Running enhances spatial pattern separation in mice
10.1073/pnas.0911725107 · doi-reference
Pattern separation in the hippocampus
10.1016/j.tins.2011.06.006 · doi-reference
Pattern separation: a common function for new neurons in hippocampus and olfactory bulb
10.1016/j.neuron.2011.05.012 · doi-reference
Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
10.1038/nature09817 · doi-reference
A functional role for adult hippocampal neurogenesis in spatial pattern separation
10.1126/science.1173215 · doi-reference
Pattern separation in the dentate gyrus and CA3 of the hippocampus
10.1126/science.1135801 · doi-reference
Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network
10.1126/science.1140263 · doi-reference
Dissociating hippocampal subregions: double dissociation between dentate gyrus and CA1
10.1002/hipo.1077 · doi-reference
Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment
10.1038/nn1696 · doi-reference
New neurons in the dentate gyrus are involved in the expression of enhanced long-term memory following environmental enrichment
10.1111/j.1460-9568.2005.03875.x · doi-reference
Neurogenesis may relate to some but not all types of hippocampal-dependent learning
10.1002/hipo.10103 · doi-reference