Abstract
Objective: This prospective clinical pilot trial aims to assess the feasibility and clinical applicability of a wireless intraoral pH sensor appliance for continuous real-time monitoring. Methods: Ten participants wore a custom-fitted intraoral pH sensor appliance over two monitoring periods of 48 and 14 h respectively. Continuous pH data was measured and recorded. In the second measurement period data could be visualized real-time on a smartphone. Results: Participants maintained a healthy intraoral pH (>6.6) for approximately half the monitoring duration (48.4%). A moderately acidic (5.9–6.6) environment was detected for 35.4%, and a highly acidic (<5.9) environment for 16.2% of the observation time. The median pH value across both visits was 6.57 (IQR:1.02). Diurnal variations showed lower daytime (median 6.65, IQR: 1.00) compared to nighttime acidity (median 6.21, IQR: 0.97), with clear pH fluctuations linked to dietary intake and resting periods. Conclusions: The wireless intraoral pH sensor wearable enabled continuous monitoring, providing reliable data on pH variations within the oral cavity over a 48-h period. Clinical Significance: The trial serves as a foundational step toward the broader clinical implementation of wearable intraoral pH sensors and real-time monitoring devices and highlights the potential of future diagnostic and therapeutic applications.