Analysis of the clinical profile of multiple endocrine neoplasia syndromes and the association with other tumors

Objective To examine the clinical profile of patients with MEN syndromes and possible associations with tumors less commonly identified in these conditions.Methods We present data from a chart review of 182 patients from our MEN registry. We identified 106 patients with MEN1 and 76 with MEN2 defined by clinical criteria. 45 patients with MEN1 and 69 with MEN2 were genetically confirmed cases.Results Among all patients with clinical MEN1, commonly associated tumors included parathyroid (89.6%), pituitary (61.3%), and gastroenteropancreatic neuroendocrine tumors (65.1%). Other tumors included papillary thyroid cancer (5.7%), renal cell carcinoma (4.7%), breast cancer, melanoma, lymphoma (1.9% each), lung cancer, bladder cancer, multiple myeloma and liposarcoma (0.9% each). Among patients with clinical MEN2, commonly associated tumors included medullary thyroid cancer (60.5%), pheochromocytoma (31.6%), and hyperparathyroidism due to parathyroid adenoma or hyperplasia (14.5%). Other tumors included breast cancer (6.6%), lymphoma (2.6%), papillary thyroid cancer (5.3%), non-small cell lung cancer, melanoma, multiple myeloma and glioblastoma multiforme (1.3% each).Conclusion The study found many tumors not commonly associated with MEN1 and MEN2 syndromes in patients with these conditions. Further investigations are needed to clarify the role of MEN1 and RET mutations in tumorigenesis to aid in early diagnosis, management, and better outcomes.