Abstract
Fragrance safety assessment requires the integration of toxicology, exposure science, and risk assessment to evaluate fragrance ingredients used across all consumer products. Since 1966, the Research Institute for Fragrance Materials (RIFM), an independent, international, non-profit scientific organization, has been advancing the safety assessment of fragrance ingredients. For six decades, RIFM has conducted and sponsored research in toxicology, exposure science, environmental assessment, and risk assessment to support the safe use of fragrance materials worldwide. Through its Safety Assessment and Research Programs, RIFM develops and evaluates scientific data, methodologies, and risk assessment approaches that inform the safe use of fragrance ingredients and provide the scientific foundation for industry risk management. This Special Issue commemorates RIFM's 60th anniversary by highlighting the Institute's historical contributions, scientific advances, and future directions in fragrance safety assessment.