Oxidative stress adaptation in aggressive prostate cancer may be counteracted by the reduction of glutathione reductase

PC3 shows higher ROS production but also the highest GSH levels and Gl‐Red activity, possibly contributing to oxidative stress resistance. This is also associated with higher mitochondrial membrane potential, TAS and lower lipid peroxidation. On the other hand, we identified Gl‐Red activity reduction as a new strategy in overcoming oxidative stress resistance, by inducing H2O2 cytotoxicity. Therefore these results suggest Gl‐Red activity reduction as a new potential therapeutic approach, in prostate cancer.