Ketogenic diet and fasting induce the expression of cold‐inducible RNA‐binding protein with time‐dependent hypothermia in the mouse liver

Cold‐inducible RNA‐binding protein (CIRBP) induced by cold stress modulates the molecular circadian clock in vitro. The present study examines the effect of a ketogenic diet (KD) and fasting on Cirbp expression in the mouse liver. Chronic KD administration induced time‐dependent Cirbp expression with hypothermia in mice. The circadian expression of clock genes such as Bmal1 and Clock was phase‐advanced and augmented in the liver of mice fed with a KD. Transient food deprivation also induced time‐dependent Cirbp expression with hypothermia in mice. These findings suggest that hypothermia is involved in the increased expression of Cirbp under ketogenic or fasting conditions.