Abstract
Per- and polyfluoroalkyl substances (PFASs) are persistent environmental contaminants that pose serious risks to ecosystems and human health. This letter discusses the future potential of potentiometric sensors as sustainable, rapid, and cost effective alternatives for PFAS monitoring. Recent advances in molecularly imprinted polymers, nanomaterials, MOFs, MXenes, and hybrid sensing platforms are evaluated regarding their contribution to sensitivity and selectivity enhancement. The integration of advanced sensing materials may enable highly effective in-situ potentiometric PFAS detection systems.