Abstract
Merve Yuce, Ipek Turkmenoglu, Gamze Kurtulus, Cenk Sesal, Ebru Demet Akten, Ozge Kurkcuoglu
Abstract
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Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management
10.1128/cmr.00134-14 · 2015
Emergence of methicillin resistance predates the clinical use of antibiotics
10.1038/s41586-021-04265-w · 2022
Allostery in disease and in drug discovery
10.1016/j.cell.2013.03.034 · 2013
Allostery in disease: from mutations, mechanisms, and Signalling partners to diagnostic and drug therapies
10.1016/j.jmb.2025.169407 · 2025
Allosteric solution to the problems of undruggable targets, drug toxicity, and emerging resistance
10.1016/j.sbi.2025.103172 · 2025
The value of protein allostery in rational anticancer drug design: an update
10.1080/17460441.2024.2384467 · 2024
Allostery: allosteric Cancer drivers and innovative allosteric drugs
10.1016/j.jmb.2022.167569 · 2022
Integrated computational approaches and tools for allosteric drug discovery
10.3390/ijms21030847 · 2020
Allo-network drugs: harnessing allostery in cellular networks
10.1016/j.tips.2011.08.004 · 2011
datacite
Confidence 0%
Allosteric sites: remote control in regulation of protein activity
10.1016/j.sbi.2015.10.004 · 2016
Rewiring enzyme regulation: allosteric drugs and predictive tools
10.1016/j.sbi.2025.103159 · 2025
Mechanism of activation and the rewired network: new drug design concepts
10.1002/med.21863 · 2022
Allosteric drugs: new principles and design approaches
10.1016/j.sbi.2023.102758 · 2024
Targeting bacterial central metabolism for drug development
10.1016/j.chembiol.2014.08.020 · 2014
Functional analysis, overexpression, and kinetic characterization of pyruvate kinase from methicillin-resistant Staphylococcus aureus
10.1021/bi100780t · 2010
Pyruvate kinase: current status of regulatory and functional properties
10.1016/s1096-4959(03)00081-2 · 2003
The allosteric regulation of pyruvate kinase
10.1074/jbc.m001870200 · 2000
Bacterial pyruvate kinase: a new potential target to combat drug-resistant Staphylococcus aureus infections
10.1002/slct.202201403 · 2022
Cheminformatics-driven discovery of selective, nanomolar inhibitors for staphylococcal pyruvate kinase
10.1021/cb2003576 · 2012
Mapping the protein interaction network in methicillin-resistant Staphylococcus aureus
10.1021/pr100918u · 2011
Identification of pyruvate kinase in methicillin-resistant Staphylococcus aureus as a novel antimicrobial drug target
10.1128/aac.01250-10 · 2011
Pyruvate kinase M2 (PKM2) in cancer and cancer therapeutics
10.1016/j.canlet.2020.11.018 · 2021
Allosteric mechanism of pyruvate kinase from Leishmania mexicana uses a rock and lock model
10.1074/jbc.m109.079905 · 2010
Allosteric pyruvate kinase-based “logic gate” synergistically senses energy and sugar levels in Mycobacterium tuberculosis
10.1038/s41467-017-02086-y · 2017
Methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as a target for Bis-indole alkaloids with antibacterial activities
10.1074/jbc.m111.289033 · 2011
Discovery and optimization of a new class of pyruvate kinase inhibitors as potential therapeutics for the treatment of methicillin-resistant Staphylococcus aureus infections
10.1016/j.bmc.2014.01.020 · 2014
Nature-inspired (di)Azine-bridged Bisindole alkaloids with potent antibacterial in vitro and in vivo efficacy against methicillin-resistant Staphylococcus aureus
10.1021/acs.jmedchem.0c00826 · 2020
Synthetic analogues of the marine Bisindole Deoxytopsentin: potent selective inhibitors of MRSA pyruvate kinase
10.1021/np500755v · 2015
Antimicrobial activity and cytotoxicity of Bis(indole) alkaloids from the sponge Spongosorites sp
10.1248/bpb.29.570 · 2006
Optimization and structure–activity relationships of a series of potent inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as novel antimicrobial agents
10.1016/j.bmc.2012.10.002 · 2012
Further investigation of inhibitors of MRSA pyruvate kinase: towards the conception of novel antimicrobial agents
10.1016/j.ejmech.2016.09.018 · 2017
Novel inhibitors of the methicillin-resistant Staphylococcus aureus (MRSA)-pyruvate kinase
10.3109/14756366.2015.1118685 · 2016
Synthesis and MRSA PK inhibitory activity of thiazole containing deoxytopsentin analogues
10.1016/j.tet.2014.09.007 · 2014
Potential allosteric sites captured in glycolytic enzymes via residue-based network models: phosphofructokinase, glyceraldehyde-3-phosphate dehydrogenase and pyruvate kinase
10.1016/j.bpc.2021.106701 · 2022
Exploring species-specific inhibitors with multiple target sites on S. Aureus pyruvate kinase using a computational workflow
10.1080/07391102.2022.2051743 · 2023
Identification of alternative allosteric sites in glycolytic enzymes for potential use as species-specific drug targets
10.3389/fmolb.2020.00088 · 2020
AlloSigMA 2: paving the way to designing allosteric effectors and to exploring allosteric effects of mutations
10.1093/nar/gkaa338 · 2020
Reversing allosteric communication: from detecting allosteric sites to inducing and tuning targeted allosteric response
10.1371/journal.pcbi.1006228 · 2018
Structure-based statistical mechanical model accounts for the causality and energetics of allosteric communication
10.1371/journal.pcbi.1004678 · 2016
Toward comprehensive allosteric control over protein activity
10.1016/j.str.2019.01.014 · 2019
Reshaping globular dynamics of S. aureus pyruvate kinase via bond restraints to allosteric sites
10.1007/s10822-025-00713-1 · doi-reference
Conformational dynamics and Allostery in pyruvate kinase
10.1074/jbc.m115.676270 · doi-reference
Thermodynamic linkages in rabbit muscle pyruvate kinase: analysis of experimental data by a two-state model
10.1021/bi00312a005 · doi-reference
‘In crystallo’ substrate binding triggers major domain movements and reveals magnesium as a co-activator of Trypanosoma brucei pyruvate kinase
10.1107/s0907444913013875 · doi-reference
Structures of pyruvate kinases display evolutionarily divergent allosteric strategies
10.1098/rsos.140120 · doi-reference
A molecular dynamics study of allosteric transitions in Leishmania mexicana pyruvate kinase
10.1016/j.bpj.2015.05.040 · doi-reference
Structural and functional linkages between subunit interfaces in mammalian pyruvate kinase
10.1006/jmbi.2001.4978 · doi-reference
Free energy calculations by the molecular mechanics Poisson−Boltzmann surface area method
10.1002/minf.201100135 · doi-reference
An overview of structure, function, and regulation of pyruvate kinases
10.1002/pro.3691 · doi-reference
Clinically approved drugs inhibit the Staphylococcus aureus multidrug NorA efflux pump and reduce biofilm formation
10.3389/fmicb.2019.02762 · doi-reference
Weighted implementation of suboptimal paths (WISP): an optimized algorithm and tool for dynamical network analysis
10.1021/ct4008603 · doi-reference
MD-TASK: a software suite for analyzing molecular dynamics trajectories
10.1093/bioinformatics/btx349 · doi-reference
Extracting the causality of correlated motions from molecular dynamics simulations
10.1016/j.bpj.2009.07.019 · doi-reference
A multi-stage computational pipeline and in vitro validation for the discovery of small-molecule translation inhibitors targeting the bacterial ribosome
10.1039/d6ra01785a · doi-reference
A computational workflow to determine drug candidates alternative to aminoglycosides targeting the decoding center of E. Coli ribosome
10.1016/j.jmgm.2024.108817 · doi-reference
A hierarchical approach to all-atom protein loop prediction
10.1002/prot.10613 · doi-reference
On the role of the crystal environment in determining protein side-chain conformations
10.1016/s0022-2836(02)00470-9 · doi-reference
Bio3d: an R package for the comparative analysis of protein structures
10.1093/bioinformatics/btl461 · doi-reference
Essential dynamics of proteins
10.1002/prot.340170408 · doi-reference
VMD: visual molecular dynamics
10.1016/0263-7855(96)00018-5 · doi-reference
A smooth particle mesh Ewald method
10.1063/1.470117 · doi-reference
Comparison of simple potential functions for simulating liquid water
10.1063/1.445869 · doi-reference
OPLS4: improving force field accuracy on challenging regimes of chemical space
10.1021/acs.jctc.1c00302 · doi-reference
On the perturbation nature of allostery: sites, mutations, and signal modulation
10.1016/j.sbi.2018.10.008 · doi-reference