Management of suspected allergy to RhD immunoglobulin in a subsequent pregnancy

Karen Ka Yin Wong; Anne K. Ellis; Karen Fung Kee Fung

doi:10.1016/j.jacig.2026.100760

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Management of suspected allergy to RhD immunoglobulin in a subsequent pregnancy

Karen Ka Yin Wong, Anne K. Ellis, Karen Fung Kee Fung

Journal of Allergy and Clinical Immunology: Global2026doi:10.1016/j.jacig.2026.100760

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Abstract

Hypersensitivity to RhD immune globulin (RhIG) used to prevent hemolytic disease of the fetus and newborn is rare. We present the management of a patient with a history of reaction to RhIG, including prenatal assessment and postnatal provision of RhIG.

Authors

Karen Ka Yin Wong#1 Anne K. Ellis#2 Karen Fung Kee Fung#3

Institutions

University of Ottawa Queen's University Ottawa Hospital

Provenance

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External reference records

Failures of intravenous Rh immune globulin prophylaxis: an analysis of the reasons for such failures

10.1016/s0887-7963(87)70010-8 · 1987

Guideline No. 448: prevention of Rh D alloimmunization

10.1016/j.jogc.2024.102449 · 2024

BCSH guideline for the use of anti-D immunoglobulin for the prevention of haemolytic disease of the fetus and newborn

10.1111/tme.12091 · 2014

Management of hypersensitivity reactions to anti-D immunoglobulin preparations

10.1111/all.12494 · 2014

Replacement of intravenous administration of anti-D by subcutaneous administration in patients with autoimmune thrombocytopenia

10.1002/pbc.21006 · 2006

Urticaria from allergy to a purified human anti-Rh antibody preparation

10.1111/j.1398-9995.1995.tb02511.x · 1995

Polysorbate 80 in medical products and nonimmunologic anaphylactoid reactions

10.1016/s1081-1206(10)61024-1 · 2005

Immediate hypersensitivity to polyethylene glycols and polysorbates: more common than we have recognized

10.1016/j.jaip.2018.12.003 · 2019

Delayed hypersensitivity to thimerosal in Rho(D) immunoglobulin

10.1016/s0091-6749(97)70206-9 · 1997

Management of suspected allergy to RhD immunoglobulin in a subsequent pregnancy

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