Menispermum dauricum rhizome alkaloids ameliorate colitis by inhibiting mitochondrial DNA synthesis via the JAK2-STAT4-AK4 pathway

Daurisoline alleviated experimental colitis in vivo and in vitro: involvement of NF-κB and Wnt/β-Catenin pathway

10.1016/j.intimp.2022.108714 · doi-reference

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

10.1038/s41586-018-0372-z · doi-reference

Circulating mitochondrial DAMPs cause inflammatory responses to injury

10.1038/nature08780 · doi-reference

Research progress on chemical constituents and pharmacological activities of Menispermi Rhizoma

10.3390/molecules28062701 · doi-reference

Pharmacokinetic and excretion study of three alkaloids in rats using UPLC-MS/MS after oral administration of Menispermi Rhizoma capsules

10.1039/c8ra04084b · doi-reference

STAT4: an immunoregulator contributing to diverse human diseases

10.7150/ijbs.41852 · doi-reference

Isolation and subsequent analysis of murine lamina propria mononuclear cells from colonic tissue

10.1038/nprot.2007.315 · doi-reference

Nuclear and mitochondrial circulating cell-free DNA is increased in patients with inflammatory bowel disease in clinical remission

10.3389/fmed.2020.593316 · doi-reference

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

10.1038/382171a0 · doi-reference

Proposed minimum reporting standards for chemical analysis Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI)

10.1007/s11306-007-0082-2 · doi-reference

Intestinal anti-inflammatory effect of the rhizome extracts of Menispermum dauricum DC. on trinitrobenzene sulfonic acid induced ulcerative colitis in mice

10.1016/j.jep.2016.07.047 · doi-reference

STAT5A–α-actinin axis links actin integrity to mitochondrial homeostasis and innate immune activation

10.1083/jcb.202601131 · doi-reference

Cardioprotective function of mitochondrial-targeted and transcriptionally inactive STAT3 against ischemia and reperfusion injury

10.1007/s00395-015-0509-2 · doi-reference

JAK-STAT pathway targeting for the treatment of inflammatory bowel disease

10.1038/s41575-020-0273-0 · doi-reference

Mitochondrial DNA in inflammation and immunity

10.15252/embr.201949799 · doi-reference

Diosgenin ameliorates colitis by inhibiting mitochondrial DNA synthesis in macrophages via STAT2-CMPK2 pathway

10.1016/j.phymed.2025.157605 · doi-reference

Digging deep into "dirty" drugs - modulation of the methylation machinery

10.3109/03602532.2014.995379 · doi-reference

10.1787/9789264071049-en

10.1787/9789264071049-en · doi-reference

Evidence-based clinical practice guidelines for inflammatory bowel disease 2020

10.1007/s00535-021-01784-1 · doi-reference

Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduce mitochondrial ROS production

10.1126/scisignal.aag2588 · doi-reference

Mitochondrial STAT3 exacerbates LPS-induced sepsis by driving CPT1a-mediated fatty acid oxidation

10.7150/thno.63751 · doi-reference

Validated LC-MS/MS method for quantitative determination of dauricine in human plasma and its application to pharmacokinetic study

10.1016/j.jchromb.2010.03.028 · doi-reference

Ulcerative colitis

10.1016/s0140-6736(23)00966-2 · doi-reference

Ulcerative colitis

10.1038/s41572-020-0205-x · doi-reference

Generic Diagramming Platform (GDP): a comprehensive database of high-quality biomedical graphics

10.1093/nar/gkae973 · doi-reference

Mitochondrial function and gastrointestinal diseases

10.1038/s41575-024-00931-2 · doi-reference

Ulcerative colitis in adults: a review

10.1001/jama.2023.15389 · doi-reference

STAT proteins - key regulators of anti-viral responses, inflammation, and tumorigenesis in the liver

10.1016/j.jhep.2012.01.029 · doi-reference

A mitochondrial STAT3-methionine metabolism axis promotes ILC2-driven allergic lung inflammation

10.1016/j.jaci.2021.12.783 · doi-reference

STAT4 gene influences genetic predisposition to ulcerative colitis but not Crohn's disease in the Spanish population: a replication study

10.1016/j.humimm.2010.02.005 · doi-reference

Mitochondrial translocation of signal transducer and activator of transcription 5 (STAT5) in leukemic T cells and cytokine-stimulated cells

10.1016/j.bbrc.2010.10.112 · doi-reference

Macrophage anti-bacterial activity is controlled by adenylate kinase 4-mediated mitochondrial DNA synthesis

10.1084/jem.20250978 · doi-reference

Adenylate kinase 4 promotes inflammatory gene expression via Hif1α and AMPK in macrophages

10.3389/fimmu.2021.630318 · doi-reference

Intestinal epithelial damage-derived mtDNA activates STING-IL12 axis in dendritic cells to promote colitis

10.7150/thno.96184 · doi-reference

Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion

10.1007/s00395-010-0124-1 · doi-reference

Gut mucosal DAMPs in IBD: from mechanisms to therapeutic implications

10.1038/mi.2016.14 · doi-reference