Heart transplant outcomes in restrictive cardiomyopathy: UNOS registry analysis of the last three decades

Background Restrictive cardiomyopathy (RCM) comprises diverse etiologies with overall poor prognosis. Emerging therapies have significantly impacted some of these entities. However, these therapies may have limited impact in the end-stages and have only recently become available. We sought to assess outcomes before and after transplant in the RCM population stratified into 3 distinct time periods from the recent era.Methods Retrospective analysis of the United Network of Organ Sharing registry (n = 62,709) for all patients transplanted between 1987 and March 1, 2022, were stratified by RCM status with 1157 patients with RCM. Populations were grouped temporally into classic (1987-2000), contemporary (2000-2013), and current (2014-2022) eras. Multiorgan and repeat transplants were excluded from the analysis. Baseline demographics, listing status, hemodynamics, donor information, and life support methods were compared using Kruskal-Wallis and Pearson's tests. Longitudinal survival was assessed via Kaplan-Meier survival analysis. Univariate and multivariate analyses using Cox modeling and competing outcomes analyses were performed.Results RCM patients were older, female, with older donors and longer ischemic times (p current era.Conclusions RCM represents a small but significant population of those requiring heart transplant. RCM transplant outcomes appear to be improving across all subsets with shorter wait times and better survival. Early recognition is important to help mitigate adverse outcomes.