Abstract
Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Kejing Zhang, Kui Chen, Xinyu Mi, Ledu Zhou
Abstract
Authors
Institutions
No ROR-resolved institution is linked to this work yet.
Provenance
crossref
Confidence 100%
pubmed
Confidence 98%
unpaywall
Confidence 95%
datacite
Confidence 0%
No local reference links have been materialized yet.
No local citing links have been materialized yet.
Targeting aerobic glycolysis combats tyrosine kinase inhibitor resistance of hepatocellular carcinoma
10.1002/ijc.70091 · 2026
Bibliometric analysis of research on liver cancer and single-cell RNA sequencing: evolutionary trends, opportunities, and future perspectives
10.1007/s44178-026-00285-6 · 2026
Immunosenescence and immunotherapy in elderly patients with hepatocellular carcinoma
10.1016/j.semcancer.2025.02.010 · 2025
Advances in immunotherapy for hepatocellular carcinoma
10.1038/s41575-021-00438-0 · 2021
Advances in immunotherapy in hepatocellular carcinoma
10.3390/ijms26051936 · 2025
Combination immunotherapy in hepatocellular carcinoma: synergies among immune checkpoints, TKIs, and chemotherapy
10.1186/s13045-025-01739-6 · 2025
Lactylation-driven NUPR1 promotes immunosuppression of tumor-infiltrating macrophages in hepatocellular carcinoma
2025
Efflux of N1-acetylspermidine from hepatoma fosters macrophage-mediated immune suppression to dampen immunotherapeutic efficacy
10.1016/j.immuni.2025.05.006 · 2025
ACLY inhibition promotes tumour immunity and suppresses liver cancer
10.1038/s41586-025-09297-0 · 2025
Targeting lactylation reinforces NK cell cytotoxicity within the tumor microenvironment
10.1038/s41590-025-02178-8 · 2025
Inflammation-induced lactate leads to rapid loss of hepatic tissue-resident NK cells
10.1016/j.celrep.2020.107855 · 2020
Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis
10.1038/s41418-021-00841-9 · 2022
Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis
10.1073/pnas.1614035114 · 2017
Riplet promotes lipid metabolism changes associated with CD8 T cell exhaustion and anti-PD-1 resistance in hepatocellular carcinoma
10.1126/sciimmunol.ado3485 · 2025
Transforming acidic coiled-coil-containing protein 3-mediated lipid metabolism reprogramming impairs CD8(+) T-cell cytotoxicity in hepatocellular carcinoma
10.1038/s41392-025-02367-9 · 2025
Dysbiotic oral microbiota-derived kynurenine, induced by chronic restraint stress, promotes head and neck squamous cell carcinoma by enhancing CD8(+) T cell exhaustion
10.1136/gutjnl-2024-333479 · 2025
Caffeine enhances antitumor T-cell activity by suppressing kynurenine pathway in colorectal cancer
10.1038/s41467-025-60958-0 · 2025
Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-kynurenine
10.1038/s41467-020-17750-z · 2020
Tryptophan metabolism in health and disease
10.1016/j.cmet.2023.06.004 · 2023
Tumor-repopulating cells induce PD-1 expression in CD8(+) T cells by transferring kynurenine and AhR activation
10.1016/j.ccell.2018.02.005 · 2018
S100A4 enhances protumor macrophage polarization by control of PPAR-γ-dependent induction of fatty acid oxidation
10.1136/jitc-2021-002548 · 2021
Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization
10.1038/s42255-024-01023-w · 2024
Impact of lipid metabolism on macrophage polarization: implications for inflammation and tumor immunity
10.3390/ijms241512032 · 2023
Metabolic engineering to facilitate anti-tumor immunity
10.1016/j.ccell.2025.02.004 · 2025
USP14-mediated metabolic competition impairs CD8+ T cell immunosurveillance in hepatocellular carcinoma
10.1073/pnas.2510576122 · 2025
Lactate: a key regulator of the immune response
10.1016/j.immuni.2025.02.008 · 2025
Shaping of innate immune response by fatty acid metabolite palmitate
10.3390/cells8121633 · 2019
Fatty acids metabolism affects the therapeutic effect of anti-PD-1/PD-L1 in tumor immune microenvironment in clear cell renal cell carcinoma
10.1186/s12967-023-04161-z · 2023
FABP5(+) lipid-loaded macrophages process tumour-derived unsaturated fatty acid signal to suppress T-cell antitumour immunity
10.1016/j.jhep.2024.09.029 · 2025
eIF3f promotes tumour malignancy by remodelling fatty acid biosynthesis in hepatocellular carcinoma
10.1016/j.jhep.2025.02.045 · 2025
Tryptophan-derived serotonin-kynurenine balance in immune activation and intestinal inflammation
10.1096/fj.202100702r · 2021
Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes
10.1136/jitc-2023-006728 · 2023
Spermine synthase engages in macrophages M2 polarization to sabotage antitumor immunity in hepatocellular carcinoma
10.1038/s41418-024-01409-z · 2025
USP2-mediated PPARγ stabilization promotes hepatocellular carcinoma progression and M2 macrophage polarization via oleic acid
10.1136/jitc-2025-012721 · 2025
Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2
10.1016/j.molcel.2021.08.024 · 2021
MINDY1 promotes breast cancer cell proliferation by stabilizing estrogen receptor α
10.1038/s41419-021-04244-z · 2021
No additional external references are available.