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Privacy-aware community infrastructureTomohiko Sugiyama, Helena Littler, Eden Kenner, Elaina Grube, Chukwunweike Odiaka, Mya Crestwell, Sasmitha Baskaran
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Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination
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Mutational processes molding the genomes of 21 breast cancers
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An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers
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An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers
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APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication
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APOBEC3A catalyzes mutation and drives carcinogenesis in vivo
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10.1084/jem.20200261 · 2020
Prospectively defined patterns of APOBEC3A mutagenesis are prevalent in human cancers
10.1016/j.celrep.2022.110555 · 2022
Distinguishing preferences of human APOBEC3A and APOBEC3B for cytosines in hairpin loops, and reflection of these preferences in APOBEC-signature cancer genome mutations
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Strand-biased cytosine deamination at the replication fork causes cytosine to thymine mutations in Escherichia coli
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APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication
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Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features
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An extended APOBEC3A mutation signature in cancer
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Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A
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APOBEC3A deaminates CTG hairpin loops to promote fragility and instability of expanded CAG/CTG repeats
10.1073/pnas.2408179122 · 2025
Family-Wide Comparative Analysis of Cytidine and Methylcytidine Deamination by Eleven Human APOBEC Proteins
10.1016/j.jmb.2017.04.021 · 2017
A DNA sequence recognition loop on APOBEC3A controls substrate specificity
10.1371/journal.pone.0097062 · 2014
Biochemical reconstitution of UV-induced mutational processes
10.1093/nar/gkz335 · 2019
Efficient base editing in methylated regions with a human APOBEC3A-Cas9 fusion
10.1038/nbt.4198 · 2018
PCNA is efficiently loaded on the DNA recombination intermediate to modulate polymerase delta, eta, and zeta activities
10.1073/pnas.1222241110 · 2013
NGS-based analysis of base-substitution signatures created by yeast DNA polymerase eta and zeta on undamaged and abasic DNA templates in vitro
10.1016/j.dnarep.2017.08.011 · 2017
Biochemical analysis of H(2)O(2)-induced mutation spectra revealed that multiple damages were involved in the mutational process
2023
Biochemical and photochemical mechanisms that produce different UV-induced mutation spectra
2021
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Deamination hotspots among APOBEC3 family members are defined by both target site sequence context and ssDNA secondary structure
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Distinct repair processes produce APOBEC-induced deletions, tandem substitutions, and complex mutations in yeast and human cells
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APOBEC3G DNA deaminase acts processively 3′ --> 5′ on single-stranded DNA
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Stochastic properties of processive cytidine DNA deaminases AID and APOBEC3G
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Visualization of uracils created by APOBEC3A using UdgX shows colocalization with RPA at stalled replication forks
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Replication protein A (RPA) hampers the processive action of APOBEC3G cytosine deaminase on single-stranded DNA
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