Abstract
Skin xenotransplantation offers a promising solution to the critical shortage of skin donors for extensive burns and complex wounds, yet its clinical translation remains hindered by fragmented research, non-standardized protocols, and regulatory hurdles. To address these challenges, we propose the establishment of the Research Consortium on Skin Xenotransplantation, a multidisciplinary platform integrating expertise in gene editing, burn medicine, biomaterials, and industrial translation. The Consortium focuses on five core missions: constructing standardized multi-gene-edited donor pigs, elucidating rejection mechanisms, developing GMP-compliant skin preservation and manufacturing technologies, conducting multicenter clinical trials, and training young investigators. By establishing collaborative mechanisms for resource sharing and joint research, the Consortium aims to streamline the translational pathway from bench to bedside, converting porcine skin xenotransplantation into a reliable, standardized clinical therapy worldwide.