Abstract
Plant responses to multifactorial stresses are shaped by coordinated regulation across multiple molecular layers. However, current epigenome editing approaches still largely focus on individual loci and often show limited and variable phenotypic effects. This gap reflects the distributed and redundant nature of regulatory networks. Here, we propose panomics-guided epigenetic programming as a framework for pathway-level regulation. By integrating panomics data, this approach facilitates the identification of key regulatory nodes and relevant control layers, and may enable coordinated perturbation of multiple targets. We further discuss general considerations for multi-node and cross-layer intervention, and illustrate how chromatin-level regulation may extend to transcriptional and protein-level processes. Potential limitations are also considered, particularly in relation to rapid post-translational regulation. Collectively, this framework provides a possible strategy for improving the stability and predictability of engineered stress responses in plants.