Small molecule antagonists of PTPmu identified by artificial intelligence-based computational screening block glioma cell migration and growth
10.1371/journal.pone.0288980 · doi-reference
A PTPmu biomarker is associated with increased survival in gliomas
10.3390/ijms20102372 · doi-reference
Proteolytic cleavage of protein tyrosine phosphatase μ regulates glioblastoma cell migration
10.1158/0008-5472.can-09-0863 · doi-reference
Targeting PTPN13 with 11-amino-acid peptides of C-terminal APC prevents immune evasion of colorectal cancer
10.1038/s41422-025-01206-4 · doi-reference
PTPN23 ubiquitination by WDR4 suppresses EGFR and c-MET degradation to define a lung cancer therapeutic target
10.1038/s41419-023-06201-4 · doi-reference
Abstract CT073: a first-in-human study of oral TNO155 (batoprotafib) alone and in combination with EGF816 (nazartinib) in adult patients with advanced solid tumors
10.1158/1538-7445.am2025-ct073 · doi-reference
Allosteric SHP2 inhibitors suppress lung cancer cell migration by inhibiting non-canonical activation of EphA2 via the ERK-RSK signaling pathway
10.1038/s41598-025-20770-8 · doi-reference
Targeting tyrosine phosphatases: time to end the stigma
10.1016/j.tips.2017.03.004 · doi-reference
SHP2-targeted cancer therapeutics: structural insights, inhibitor development and emerging modalities
10.1016/j.bmc.2026.118708 · doi-reference
Recent advances in the development of allosteric protein tyrosine phosphatase inhibitors for drug discovery
10.1002/med.21871 · doi-reference
Elevated protein tyrosine phosphatase kappa expression is associated with disease progression and poor prognosis of pancreatic cancer
10.21873/cdp.10560 · doi-reference
PTPRK regulates glycolysis and de novo lipogenesis to promote hepatocyte metabolic reprogramming in obesity
10.1038/s41467-024-53733-0 · doi-reference
The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer
10.7554/elife.51248 · doi-reference
Molecular mechanism of Afadin substrate recruitment to the receptor phosphatase PTPRK via its pseudophosphatase domain
10.7554/elife.79855 · doi-reference
Determinants of receptor tyrosine phosphatase homophilic adhesion: structural comparison of PTPRK and PTPRM extracellular domains
10.1016/j.jbc.2022.102750 · doi-reference
Identification of phospholipase C gamma1 as a protein tyrosine phosphatase mu substrate that regulates cell migration
10.1002/jcb.22710 · doi-reference
Involvement of nectin in inactivation of integrin αvβ3 after the establishment of cell-cell adhesion
10.1074/jbc.m704195200 · doi-reference
Association of connexin43 with a receptor protein tyrosine phosphatase
10.1080/cac.10.4-6.201.205 · doi-reference
The receptor protein-tyrosine phosphatase PTPμ interacts with IQGAP1
10.1074/jbc.m506414200 · doi-reference
Expression of the receptor protein-tyrosine phosphatase, PTPμ, restores E-cadherin-dependent adhesion in human prostate carcinoma cells
10.1074/jbc.m112157200 · doi-reference
The PTPμ protein-tyrosine phosphatase binds and recruits the scaffolding protein RACK1 to cell-cell contacts
10.1074/jbc.m010823200 · doi-reference
Receptor protein-tyrosine phosphatase RPTPμ binds to and dephosphorylates the catenin p120ctn
10.1074/jbc.275.15.11264 · doi-reference
Molecular basis of class III ligand recognition by PDZ3 in murine protein tyrosine phosphatase PTPN13
10.1016/j.jmb.2018.08.023 · doi-reference
The protein kinase C-related kinase PRK2 interacts with the protein tyrosine phosphatase PTP-BL via a novel PDZ domain binding motif
10.1016/s0014-5793(01)02401-2 · doi-reference
PTPN13 regulates cellular signalling and β-catenin function during megakaryocytic differentiation
10.1016/j.bbamcr.2014.08.014 · doi-reference
The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain
10.1038/sj.onc.1203725 · doi-reference
The binding affinity of PTPN13’s tandem PDZ2/3 domain is allosterically modulated
10.1186/s12860-019-0203-6 · doi-reference
Protein tyrosine phosphatase-N13 promotes myofibroblast resistance to apoptosis in idiopathic pulmonary fibrosis
10.1164/rccm.201707-1497oc · doi-reference
PTPL1: a large phosphatase with a split personality
10.1007/s10555-008-9114-2 · doi-reference
ESCRT-I and PTPN23 mediate microautophagy of ubiquitylated tau aggregates
10.1083/jcb.202406120 · doi-reference
A non-canonical ESCRT pathway, including histidine domain phosphotyrosine phosphatase (HD-PTP), is used for down-regulation of virally ubiquitinated MHC class I
10.1042/bj20150336 · doi-reference
Endofin is required for HD-PTP and ESCRT-0 interdependent endosomal sorting of ubiquitinated transmembrane cargoes
10.1016/j.isci.2021.103274 · doi-reference
Haploinsufficiency of the ESCRT component HD-PTP predisposes to cancer
10.1016/j.celrep.2016.04.076 · doi-reference
Recruitment of UBPY and ESCRT exchange drive HD-PTP-dependent sorting of EGFR to the MVB
10.1016/j.cub.2013.02.033 · doi-reference
Dissecting the role of His domain protein tyrosine phosphatase/PTPN23 and ESCRTs in sorting activated epidermal growth factor receptor to the multivesicular body
10.1042/bst20170443 · doi-reference
The open architecture of HD-PTP phosphatase provides new insights into the mechanism of regulation of ESCRT function
10.1038/s41598-017-09467-9 · doi-reference
HD-PTP is a catalytically inactive tyrosine phosphatase due to a conserved divergence in its phosphatase domain
10.1371/journal.pone.0005105 · doi-reference
Effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on interleukin-3 signaling
10.1074/jbc.m507622200 · doi-reference
