Abstract
We present a rare case of colonic mucormycosis with hepatic dissemination after kidney transplantation. Early diagnosis was achieved through rapid metagenomic next-generation sequencing (mNGS) of blood and liver abscess samples, enabling timely intervention. The patient achieved complete clinical recovery with preserved allograft function. Gastrointestinal mucormycosis is extremely rare, reported cases frequently require colectomy (83.3%) and carry a mortality rate approaching 50%. This case highlights key management principles for intestinal mucormycosis in transplant recipients: rapid pathogen identification via mNGS, prompt initiation of dual antifungal therapy against Mucorales, and urgent surgical debridement of necrotic tissue.