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Privacy-aware community infrastructureJonathan D. Smith
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Severity of cardiovascular disease, apolipoprotein E genotype and brain pathology in aging and dementia
10.1111/j.1749-6632.2000.tb06374.x · 2000
Apolipoprotein E polymorphism is not associated with longevity or disability in a sample of Italian octo- and nonagenarians
10.1159/000022030 · 1998
Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition
10.1038/ng1197-263 · 1997
Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer’s disease
10.1073/pnas.96.26.15233 · 1999
Isoform-specific modulation by apolipoprotein E of the activities of secreted β-amyloid precursor protein
10.1046/j.1471-4159.1997.69010060.x · 1997
The apoE influences declarative and procedural learning in age-associated memory impairment
10.1097/00001756-199909290-00009 · 1999
β-Amyloid peptides increase the binding and internalization of apolipoprotein E to hippocampal neurons
10.1046/j.1471-4159.1998.70041458.x · 1998
Early effect of apoE-ε4 allele on cognitive results in a group of highly performing subjects: the EVA study. Etude sur le Vieillissement Arteriel
10.1016/0304-3940(96)13059-7 · 1996
Rapid induction of intraneuronal neurofibrillary tangles in apolipoprotein E-deficient mice
10.1073/pnas.151253098 · 2001
Co-expression of β-amyloid precursor protein (β-APP) and apolipoprotein E in cell culture: analysis of β-APP processing
10.1006/nbdi.1995.0019 · 1995
The apoE4 and age at onset of Alzheimer’s disease—the NIMH genetics initiative
10.1212/wnl.48.1.139 · 1997
A study of French centenarians: are ACE and apoE associated with longevity?
10.1016/s0764-4469(00)01274-9 · 2001
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins
10.1016/s0896-6273(00)80974-5 · 1997
Apolipoprotein E associated with astrocytic glia of the central nervous system and with non-myelinating glia of the peripheral nervous system
10.1172/jci112130 · 1985
Evidence for an interaction between apolipoprotein E genotype, gender and Alzheimer’s disease
10.1097/00002093-199910000-00007 · 1999
A polymorphism in the regulatory region of apoE associated with risk for Alzheimer’s dementia: in process citation
10.1038/ng0198-69 · 1998
Human apolipoprotein E4 accelerates β-amyloid deposition in APPsw transgenic mouse brain
10.1002/ana.1134 · 2001
Pre-clinical cognitive decline in late middle-aged asymptomatic apolipoprotein E-ε4/4 homozygotes: a replication study
10.1016/s0022-510x(01)00577-9 · 2001
Endocytic pathway abnormalities precede amyloid β-deposition in sporadic Alzheimer’s disease and Down syndrome: differential effects of apoE genotype and presenilin mutations
10.1016/s0002-9440(10)64538-5 · 2000
The apoE allele frequencies in younger (age 42–50) versus older (age 65–90) women
10.1002/gepi.1370100104 · 1993
Apolipoprotein E polymorphism: a new genetic marker of hip fracture risk—the study of osteoporotic fractures
10.1359/jbmr.1999.14.7.1175 · 1999
Age-related cognitive decline, mild cognitive impairment or pre-clinical Alzheimer’s disease?
10.3109/07853890008995904 · 2000
Effect of apolipoprotein E genotype on hippocampal volume loss in aging healthy women
10.1212/wnl.57.12.2223 · 2001
Lipoprotein effects on a β-accumulation and degradation by microglia in vitro
10.1002/(sici)1097-4547(19990815)57:4<504::aid-jnr10>3.0.co;2-h · 1999
Memory decline in healthy older people: implications for identifying mild cognitive impairment
10.1212/wnl.56.11.1533 · 2001
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families
10.1126/science.8346443 · 1993
Apolipoprotein E genotype determines survival in the oldest old (85 years or older) who have good cognition
10.1001/archneur.1996.00550050048022 · 1996
Accelerated decline in apolipoprotein E-ε4 homozygotes with Alzheimer’s disease
10.1212/wnl.51.1.149 · 1998
Apolipoprotein E polymorphism and atherosclerosis
10.1161/01.atv.8.1.1 · 1988
Prediction of cognitive decline in normal elderly subjects with 2-[18F]fluoro-2-deoxy-d-glucose/poitron emission tomography (FDG/PET)
10.1073/pnas.191044198 · 2001
Cerebrovascular and brain morphologic correlates of mild cognitive impairment in the National Heart, Lung and Blood Institute twin study
10.1001/archneur.58.4.643 · 2001
The endosomal trafficking of apolipoprotein E3 and E4 in cultured human brain neurons and astrocytes
10.1006/nbdi.2000.0362 · 2001
Stroke and apolipoprotein E-ε4 are independent risk factors for cognitive decline: a population-based study
10.1161/01.str.31.10.2431 · 2000
Memory complaints and apoE-ε4 accelerate cognitive decline in cognitively normal elderly
10.1212/wnl.57.12.2217 · 2001
Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms
10.1016/s0021-9258(17)31797-0 · 1994
Interaction of the apolipoprotein E and CI loci in predisposing to late-onset Alzheimer’s disease
10.1212/wnl.51.1.131 · 1998
β-Amyloid peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a pro-inflammatory pathway in Alzheimer disease
10.1073/pnas.94.10.5296 · 1997
Microglial activation in Alzheimer disease: association with apoE genotype
10.1111/j.1750-3639.1998.tb00166.x · 1998
Apolipoprotein E polymorphism in the Finnish population: gene frequencies and relation to lipoprotein concentrations
10.1016/s0022-2275(20)38833-7 · 1986
Polymorphisms of the apolipoprotein B and E genes and their relationship to plasma lipid variables in healthy Chinese men
10.1007/bf00219691 · 1993
Intelligence and event-related potentials for young female human volunteer apolipoprotein E-ε4 and non-ε4 carriers
10.1016/s0304-3940(00)01569-x · doi-reference
Apolipoprotein E promotes the binding and uptake of β-amyloid into Chinese hamster ovary cells in an isoform-specific manner
10.1016/s0306-4522(98)00561-2 · doi-reference
Alzheimer β-amyloid deposition enhanced by apoE-ε4 gene precedes neurofibrillary pathology in the frontal association cortex of nondemented senior subjects
10.1093/jnen/60.7.731 · doi-reference
Influences of common variants of apolipoprotein E on measures of lipid metabolism in a sample selected for health
10.1161/01.atv.11.4.1100 · doi-reference
Apolipoprotein E alleles and risk of coronary disease: a meta-analysis
10.1161/01.atv.16.10.1250 · doi-reference
Apolipoprotein E4 promotes incipient Alzheimer pathology in the elderly
10.1097/00002093-199803000-00005 · doi-reference
Osteoporosis and apolipoprotein E genotype in older adults: the Rancho Bernardo study
10.1007/s001980170124 · doi-reference
Astrocytes down-regulate neuronal β-amyloid precursor protein expression and modify its processing in an apolipoprotein E isoform-specific manner
10.1046/j.0953-816x.2001.01643.x · doi-reference
No association between apolipoprotein E polymorphisms and general cognitive ability in children
10.1016/s0304-3940(00)01789-4 · doi-reference
Apolipoprotein E phenotypes in demented and cognitively impaired patients with and without cerebrovascular disease
10.1046/j.1468-1331.1999.640415.x · doi-reference
Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer’s amyloid β-peptides
10.1042/0264-6021:3480359 · doi-reference
Human apolipoprotein E isoform-specific differences in neuronal sprouting in organotypic hippocampal culture
10.1046/j.1471-4159.1999.0732613.x · doi-reference
Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice
10.1016/s0002-9440(10)64963-2 · doi-reference
Preliminary report of a genetic basis for cognitive decline after cardiac operations: the neurologic outcome research group of the Duke heart center
10.1016/s0003-4975(97)00757-1 · doi-reference
Incidence of AD in African–Americans, Caribbean Hispanics and Caucasians in northern Manhattan
10.1212/wnl.56.1.49 · doi-reference
The apoE-ε4 allele and the risk of Alzheimer’s disease among African–Americans, whites and Hispanics
10.1001/jama.279.10.751 · doi-reference
Apolipoprotein E phenotype regulates cholesterol absorption in healthy 13-month-old children—the STRIP study
10.1203/00006450-200112000-00010 · doi-reference
Isoform-specific interactions of apoE with microtubule-associated protein tau: implications for Alzheimer disease
10.1073/pnas.91.23.11183 · doi-reference
Apolipoprotein E genotype, vascular risk and early cognitive impairment in an African–Caribbean population
10.1159/000051267 · doi-reference
An ecological study of association between coronary heart disease mortality rates in men and the relative frequencies of common allelic variations in the gene coding for apolipoprotein E
10.1007/s004390050811 · doi-reference
Apolipoprotein E polymorphism predicts death from coronary heart disease in a longitudinal study of elderly Finnish men
10.1161/01.cir.91.2.265 · doi-reference
Apolipoprotein E genotypes and cognitive functions in healthy elderly persons
10.1111/j.1600-0404.1999.tb00723.x · doi-reference
Human apolipoprotein E allele-specific brain expressing transgenic mice
10.1016/s0197-4580(98)00076-1 · doi-reference
Apolipoprotein E genotype influences cognitive phenotype in patients with Alzheimer’s disease but not in healthy control subjects
10.1212/wnl.50.2.355 · doi-reference
Apolipoprotein E4: an allele associated with many diseases
10.3109/07853890009011761 · doi-reference
Apolipoprotein E polymorphism in The Netherlands and its effect on plasma lipid and apolipoprotein levels
10.1007/bf01790099 · doi-reference
Is apoE-ε4 a risk factor for cognitive impairment in normal aging?
10.1212/wnl.54.11.2082 · doi-reference
Three-year changes in cognitive performance as a function of apolipoprotein E genotype: evidence from very old adults without dementia
10.1037/0882-7974.13.1.80 · doi-reference
Apolipoprotein E genotype and progression of Alzheimer’s disease: the Rotterdam study
10.1007/s004150050351 · doi-reference
The effect of APOE on dementia is not through atherosclerosis: the Rotterdam study
10.1212/wnl.53.7.1593 · doi-reference
Distribution of geriatric disease-related genotypes in the National Institute for Longevity Sciences’ longitudinal study of aging (NILS-LSA)
10.2188/jea.10.1sup_46 · doi-reference
Duplicated downstream enhancers control expression of the human apolipoprotein E gene in macrophages and adipose tissue
10.1074/jbc.m005468200 · doi-reference
Human apolipoprotein E accelerates microtubule polymerization in vitro
10.1016/s0304-3940(98)00180-3 · doi-reference
Apolipoprotein E-ε4 allele in the normal elderly: neuropsychologic and brain MRI correlates
10.1111/j.1399-0004.1996.tb02377.x · doi-reference
Increased amyloid β-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease
10.1073/pnas.90.20.9649 · doi-reference
Apolipoprotein E polymorphism: survival and neurological outcome after cardiopulmonary resuscitation
10.1161/01.str.31.9.2068 · doi-reference
Genetic associations with human longevity at the apoE and ACE loci
10.1038/ng0194-29 · doi-reference
Association of apolipoprotein E allele ε4 with late-onset familial and sporadic Alzheimer’s disease
10.1212/wnl.43.8.1467 · doi-reference
The apoE associates with β-amyloid peptide of Alzheimer’s disease to form novel monofibrils
10.1172/jci117407 · doi-reference
Susceptibility of transgenic mice expressing human apolipoprotein E to closed head injury: the allele E3 is neuroprotective whereas E4 increases fatalities
10.1016/s0306-4522(00)00438-3 · doi-reference