Abstract
Abstract
Background:
Children with ventricular septal defects experience chronic left-to-right shunting, resulting in ventricular volume overload and alterations in myocardial electrical properties. Data on ventricular electrical remodelling following closure, particularly regarding closure technique, remain limited.
Objectıve:
To evaluate ventricular depolarisation and repolarisation indices in children with isolated ventricular septal defects before and after closure and to compare the outcomes of surgical and transcatheter approaches.
Methods:
This retrospective, single-centre study included 58 children aged 4–18 months who underwent isolated ventricular septal defect closure (transcatheter,
n
= 25; surgical,
n
= 33) and 40 age- and sex-matched healthy controls. Standard 12-lead electrocardiograms recorded before the procedure and at six months after closure were analysed. Multiple ventricular depolarisation and repolarisation indices were assessed.
Results:
Before closure, children with ventricular septal defects demonstrated significant abnormalities in ventricular depolarisation and repolarisation indices compared with healthy controls (all
p
Conclusion:
Children with isolated ventricular septal defects demonstrate subclinical alterations in ventricular depolarisation and repolarisation. Defect closure is associated with substantial improvement in ventricular repolarisation; however, depolarisation abnormalities may persist during mid-term follow-up irrespective of closure technique.