DDB2 represses ovarian cancer cell dedifferentiation by suppressing ALDH1A1
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Characterization of SOX2, OCT4 and NANOG in ovarian cancer tumor-initiating cells
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S-palmitoylation of c-MET by CK2α-mediated zDHHC15 phosphorylation drives glioblastoma stem cell tumorigenicity
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CK2α deletion in the hematopoietic compartment shows a mild alteration in terminally differentiated cells and the expansion of stem cells
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The WT1 protein molecule drives the proliferation and metastasis of anaplastic thyroid carcinoma through the EMT process
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Phosphorylation-dependent stabilization of MZF1 upregulates N-cadherin expression during protein kinase CK2-mediated epithelial-mesenchymal transition
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PARP1 bound to XRCC2 promotes tumor progression in colorectal cancer
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Lidocaine inhibits the metastatic potential of ovarian cancer by blocking NaV1.5-mediated EMT and FAK/Paxillin signaling pathway
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Superenhancers shape the landscape and repair dynamics of transcription-associated DNA breaks in cancer
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Impaired PARP1-dependent DNA repair in MORC2 mutations drives axonal degeneration in Charcot-Marie-Tooth disease subtype 2Z and spinal muscular atrophy-like neuromotor disorders
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PARP1 inhibitors: antitumor drug design
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Design, synthesis, and biological evaluation of a series of benzofuran[3,2-d] pyrimidine-4(3H)-one derivatives containing thiosemicarbazone analogs as novel PARP-1 inhibitors
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Artificial intelligence in drug discovery: Integrative advances from data to therapeutic innovation
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Artificial intelligence in drug discovery and development: transforming pharmaceutical innovation
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Overlapping roles for PARP1 and PARP2 in the recruitment of endogenous XRCC1 and PNKP into oxidized chromatin
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Prevalence and prognosis of BRCAm, homologous recombination repair mutation (HRRm) or HR deficiency positive (HRD+) across tumor types
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PARP inhibitors in pancreatic cancer: molecular mechanisms and clinical applications
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CRISPR-Cas9 fusion to dominant-negative 53BP1 enhances HDR and inhibits NHEJ specifically at Cas9 target sites
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PS4-05-30: Maged1 inhibition enhances sensitivity to parp inhibitors in brca-mutated breast cancer cells
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PARP inhibitors target cellular energy metabolism: Mechanisms of action and clinical implications
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Abstract CT271: Clinical trial in progress: BCC021 Phase I/II study of Silmitasertib (CX-4945) in combination with chemotherapy in children and young adults with relapsed refractory solid tumors
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an FDA-designated orphan CK2 inhibitor, ameliorates neuropathology and motor dysfunction in a Huntington’s disease mouse model
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CK2α causes stemness and chemotherapy resistance in liver cancer through the Hedgehog signaling pathway
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Novel CK2-specific Pt(II) compound reverses cisplatin-induced resistance by inhibiting cancer cell stemness and suppressing DNA damage repair in non-small cell lung cancer treatments
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CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response
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XRCC1 phosphorylation by CK2 is required for its stability and efficient DNA repair
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Regulation of cancer progression by CK2: an emerging therapeutic target
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A comprehensive review on the dynamics of protein kinase CK2 in cancer development and optimizing therapeutic strategies
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Discovery of 5-(3-chlorophenylamino)benzo[c] [2,6]naphthyridine derivatives as highly selective CK2 inhibitors with potent cancer cell stemness inhibition
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Inhibiting CK2 in breast cancer: From molecular targets to drug candidates
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Clinical use and mechanisms of resistance for PARP inhibitors in homologous recombination-deficient cancers
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Doubling down on the PI3K-AKT-mTOR pathway enhances the antitumor efficacy of PARP inhibitor in triple negative breast cancer model beyond BRCA-ness
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The poly (ADP ribose) polymerase inhibitor niraparib: Management of toxicities
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Efficacy and safety of PARP inhibitors in the treatment of advanced ovarian cancer: An updated systematic review and meta-analysis of randomized controlled trials
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In vitro analysis of PARP inhibitor nanoformulations
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Advancements in nanotechnology for PARP inhibitor delivery: a comprehensive review of diverse nanosystems, their mechanisms, and therapeutic applications across cancer and beyond
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Discovery of a dual tubulin and poly(ADP-ribose) polymerase-1 inhibitor by structure-based pharmacophore modeling, virtual screening, molecular docking, and biological evaluation
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Clinical application of PARP inhibitors and emerging strategies to overcome resistance: a pan-cancer perspective
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Combined PARP inhibitors and small molecular inhibitors in solid tumor treatment
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