Synthesis and Antiviral Activity Evaluation of Nitroporphyrins and Nitrocorroles as Potential Agents against Human Cytomegalovirus Infection

Claude P. Gros; Nicolas Desbois; Clément Michelin; Eloise Demilly; Anne‐Françoise Tilkin‐Mariamé; Bernard Mariamé; Franck Gallardo

doi:10.1021/acsinfecdis.5b00020

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Synthesis and Antiviral Activity Evaluation of Nitroporphyrins and Nitrocorroles as Potential Agents against Human Cytomegalovirus Infection

Claude P. Gros, Nicolas Desbois, Clément Michelin, Eloise Demilly, Anne‐Françoise Tilkin‐Mariamé, Bernard Mariamé, Franck Gallardo

ACS Infectious Diseases2015doi:10.1021/acsinfecdis.5b00020

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Abstract

Different nitroporphyrinoid derivatives were synthesized and studied as potential agents against human Cytomegalovirus. Interestingly, two nitrocorroles display strong activity against human Cytomegalovirus with IC 50 < 0.5 μM. These compounds also possess antiproliferative activities without detected in vivo toxicity. Therefore, nitrocorroles appear for the first time as potential active compounds that can be applied in human health.

Authors

Claude P. Gros#1 Nicolas Desbois#2 Clément Michelin#3 Eloise Demilly#4 Anne‐Françoise Tilkin‐Mariamé#5 Bernard Mariamé#6 Franck Gallardo#7

Institutions

Université de Bourgogne

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External reference records

10.1023/a:1014779614525

10.1002/rmv.655

10.1128/cmr.00009-10

10.1021/ic202204u

10.1021/mp200094w

10.1002/chem.200800835

10.1039/c4cc06577h

10.1007/s11095-005-9225-1

10.1016/j.ccr.2010.09.013

10.1016/j.bmcl.2005.05.044

10.1128/aac.00989-10

10.1021/jo005661t

Synthesis and Antiviral Activity Evaluation of Nitroporphyrins and Nitrocorroles as Potential Agents against Human Cytomegalovirus Infection

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