Stopping Trouble before It Starts

Jon Clardy

doi:10.1021/cb0600029

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Stopping Trouble before It Starts

Jon Clardy

ACS Chemical Biology2006doi:10.1021/cb0600029

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Abstract

A recent publication revealing that the cytotoxic marine natural product pateamine A targets eukaryotic initiation factor eIF4A continues a story with lessons for both chemists and biologists, that is, the significance of natural products, the importance of synthetic organic chemistry, the small molecule regulation of eukaryotic translation machinery, and possibly a new approach to cancer chemotherapy.

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Jon Clardy#1

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External reference records

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10.1016/0040-4039(91)80182-6

10.1016/0040-4039(91)80182-6 · 1991

10.1073/pnas.0504249102

10.1073/pnas.0504249102 · 2005

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10.1073/pnas.0501424102

10.1073/pnas.0501424102 · 2005

10.1002/cbic.200500210

10.1002/cbic.200500210 · 2005

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