Opinion:: Resolution of Lyme Arthritis, Acute or Prolonged: A New Look

I have presented a paradigm for the pathogenesis and resolution of Lyme arthritis founded upon the clinical facts that describe its natural history, and centered about a process of intermittent immune recognition of what may sometimes be an array of antigenic variants. The model applies both to acute and to prolonged (chronic) disease. If it proves to be correct, it represents a variation of the struggle between parasite and host that is probably not limited to Lyme disease.