Multiple solid-phase synthesis of hydantoins and thiohydantoins

Gurdip Bhalay; Daniel Cowell; Neal D. Hone; Martin Scobie; Anthony D. Baxter

doi:10.1023/a:1009612923900

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Multiple solid-phase synthesis of hydantoins and thiohydantoins

Gurdip Bhalay, Daniel Cowell, Neal D. Hone, Martin Scobie, Anthony D. Baxter

Molecular Diversity1997doi:10.1023/a:1009612923900

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Abstract

A novel general protocol for the construction of hydantoins and thiohydantoins on a solid support has been developed. Using this novel methodology, the synthesis of a diverse 96-compound library has been achieved. Resin-bound dipeptides are cyclised via the formation of an intermediate isocyanate or isothiocyanate on resin as the key step in the strategy.

Authors

Gurdip Bhalay#1 Daniel Cowell#2 Neal D. Hone#3 Martin Scobie#4 Anthony D. Baxter#5

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External reference records

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