A safety-catch linker for amine release under biologically compatible conditions

David Orain

doi:10.1023/a:1011355300910

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A safety-catch linker for amine release under biologically compatible conditions

David Orain

Molecular Diversity2000doi:10.1023/a:1011355300910

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Abstract

A 'biocompatible' safety-catch linker based on an internal diketopiperazine release has been developed to allow the release of amine based compounds. The synthesis of the linker and its pre-loading with a representative set of amines is described. After immobilization onto an amino Tentagel resin, the linker was activated and the amines were released under biological conditions at pH 8.

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David Orain#1

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A safety-catch linker for amine release under biologically compatible conditions

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