Combinatorial approaches to inhibitors of VLA-4: Piperazine-peptoid-bisarylureas

Ian Lewis; Bernhard Rohde; Marc Mengus; Marla Weetall; Susan Maida; Ron Hugo; Philip Lake

doi:10.1023/a:1013990624215

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Combinatorial approaches to inhibitors of VLA-4: Piperazine-peptoid-bisarylureas

Ian Lewis, Bernhard Rohde, Marc Mengus, Marla Weetall, Susan Maida, Ron Hugo, Philip Lake

Molecular Diversity2000doi:10.1023/a:1013990624215

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Abstract

A combinatorial approach towards identifying inhibitors of VALA-4 was investigated. A library of piperazine-peptoid-bisarylureas was assembled in solid phase and screening in the novel v-well assay enabled the identification of active compounds.

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Ian Lewis#1 Bernhard Rohde#2 Marc Mengus#3 Marla Weetall#4 Susan Maida#5 Ron Hugo#6 Philip Lake#7

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Combinatorial approaches to inhibitors of VLA-4: Piperazine-peptoid-bisarylureas

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