Preparation of N-alkylated 5-oxo-3-carboxamyl-1,4-thiazinanes on solid support

Reza Mortezaei; Satoru Ida; David A. Campbell

doi:10.1023/a:1026443620544

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Preparation of N-alkylated 5-oxo-3-carboxamyl-1,4-thiazinanes on solid support

Reza Mortezaei, Satoru Ida, David A. Campbell

Molecular Diversity1998doi:10.1023/a:1026443620544

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Abstract

A general method was developed to generate six-membered cyclic thiazinanes on solid support. Three diversity sites were introduced into this scaffold using primary amines, aldehydes, and 2-bromoalkanoic acids. The methodology to prepare individual cyclic thiazinanes as well as combinatorial libraries of these compounds is described.

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Reza Mortezaei#1 Satoru Ida#2 David A. Campbell#3

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Preparation of N-alkylated 5-oxo-3-carboxamyl-1,4-thiazinanes on solid support

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