Abstract
Objectives
The association between nocturnal intermittent hypoxia and metabolic syndrome (MetS) in individuals without abdominal obesity has not yet been fully explored. We conducted a longitudinal study to investigate the association between nocturnal intermittent hypoxia and the incidence of MetS and its components in Japanese individuals without abdominal obesity.Methods
This prospective cohort study included 647 participants without baseline MetS and abdominal obesity, defined as a waist circumference of Results
In the younger age group, 3% ODI ≥ 5 was associated with a significantly higher risk ratio (RR) for MetS incidence (RR 2.10, 95% confidence interval [CI]: 1.18-3.76). Participants with 3% ODI ≥ 5 in the younger age group also had significantly higher RRs for abdominal obesity (RR 2.17, 95% CI: 1.42-3.33), low high-density lipoprotein cholesterol (RR 2.01, 95% CI: 1.02-3.96), and hypertriglyceridemia (RR 2.41, 95% CI: 1.35-4.30). In the older age group, 3% ODI ≥ 5 was not significantly associated with increased RRs for MetS or its components.Conclusions
Nocturnal intermittent hypoxia was associated with an increased risk of developing MetS and some of its components in younger individuals without abdominal obesity.