Applying a systemic approach that extends beyond the brain to Alzheimer’s disease pathogenesis

Payam Barnaghi; Antigone Fogel; Chloe Walsh; Ramin Nilforooshan; Valeria Ricotti; Thomas Voit

doi:10.1038/s43856-026-01831-z

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Applying a systemic approach that extends beyond the brain to Alzheimer’s disease pathogenesis

Payam Barnaghi, Antigone Fogel, Chloe Walsh, Ramin Nilforooshan, Valeria Ricotti, Thomas Voit

Communications Medicine2026doi:10.1038/s43856-026-01831-z

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Abstract

Traditional dementia research often isolates single aspects, biomarkers or symptoms, overlooking complex interactions shaping disease risk and progression. Lysosomal and mitochondrial dysfunction, reflecting systemic processes, may explain links between Alzheimer’s and metabolic, inflammatory, cardiovascular, ageing, genetic, environmental, and endocrine factors.

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Payam Barnaghi#1 Antigone Fogel#2 Chloe Walsh#3 Ramin Nilforooshan#4 Valeria Ricotti#5 Thomas Voit#6

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Applying a systemic approach that extends beyond the brain to Alzheimer’s disease pathogenesis

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