Advancements in RNA-based therapies from bench to bedside

Amrita Singh; Muktika Tekade; Sreeharsha Nagaraja; Azad Bharti; Rakesh Kumar Tekade

doi:10.1038/s44386-025-00037-y

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Advancements in RNA-based therapies from bench to bedside

Amrita Singh, Muktika Tekade, Sreeharsha Nagaraja, Azad Bharti, Rakesh Kumar Tekade

npj Drug Discovery2026doi:10.1038/s44386-025-00037-y

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Abstract

Abstract RNA research has advanced rapidly, becoming a key component of modern therapeutics. This review outlines key milestones and innovations from antisense oligonucleotides and RNA interference to mRNA therapies and aptamers that have enabled targeted treatments for diverse diseases. The success of COVID-19 mRNA vaccines highlighted the remarkable clinical potential of RNA-based technologies. Emphasis is placed on delivery technologies, landmark approvals, and ongoing trials shaping the future of RNA-based medicine.

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Authors

Amrita Singh#1 Muktika Tekade#2 Sreeharsha Nagaraja#3 Azad Bharti#4 Rakesh Kumar Tekade#5

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Advancements in RNA-based therapies from bench to bedside

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