Targeting druggable kinases in neuropathic pain

Despite the prevalence of neuropathic pain and the opioid crisis, there has been little progress in the development of non-opioid alternative therapies. Protein kinases orchestrate multiple key pathophysiological events in the progression of pain signaling pathways. This review highlights druggable kinases and the associated scaffolds as well as molecular modalities to reverse mechanical allodynia and thermal hyperalgesia in neuropathy models whether preclinically or clinically.