Induced proximity-based therapeutics for advanced prostate cancer

John Ching; Cindy H. Chau; William D. Figg

doi:10.1038/s44386-026-00062-5

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Induced proximity-based therapeutics for advanced prostate cancer

John Ching, Cindy H. Chau, William D. Figg

npj Drug Discovery2026doi:10.1038/s44386-026-00062-5

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Abstract

Abstract Metastatic castration-resistant prostate cancers (mCRPC) remain dependent on androgen receptor (AR) signaling despite resistance to androgen-deprivation and AR-targeted therapies. Induced proximity-based therapeutics employ event-driven pharmacology to target AR, potentially overcoming resistance mechanisms. Herein, we highlight recent advances in induced proximity strategies targeting AR in mCRPC.

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Authors

John Ching#1 Cindy H. Chau#2 William D. Figg#3

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1941

10.1038/s41388-025-03573-z

10.1038/s41388-025-03573-z · 2025

10.1038/s41573-025-01316-z

10.1038/s41573-025-01316-z · 2025

10.1073/pnas.141230798

10.1073/pnas.141230798 · 2001

Unresolved referenced work

Kept as external metadata until matched

10.1038/s41573-021-00371-6

10.1038/s41573-021-00371-6 · 2022

10.1158/1535-7163.mct-23-0655

10.1158/1535-7163.mct-23-0655 · 2025

10.1158/1078-0432.ccr-25-0471

10.1158/1078-0432.ccr-25-0471 · 2026

10.1016/j.annonc.2024.09.005

10.1016/j.annonc.2024.09.005 · 2025

10.1159/000447176

10.1159/000447176 · 2017

10.1007/s40262-015-0271-5

10.1007/s40262-015-0271-5 · 2015

10.3389/fonc.2025.1748527

10.3389/fonc.2025.1748527 · 2025

10.3389/fendo.2024.1437179

Induced proximity-based therapeutics for advanced prostate cancer

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