Lowering of circulating insulin and leptin is closely associated following weight reduction after vertical banded gastroplasty in obese women

Summary Aim : To explore whether the lowering of insulin relates to changes in leptin following weight reduction after vertical banded gastroplasty (VBG) in seven grossly obese women (BMI 45.9 ± 1.5 kg/m 2 ). Results : At 6–24 months after VBG, BMI was reduced to 31.3 ± 0.9 kg/m 2 (p r  = 0.94, p = 0.002) but not to that of BMI ( r  = 0.05, NS). Conclusion : Reduction in insulin seems more important for reduction in leptin than lowering of BMI, suggesting a close association between leptin and insulin in obese subjects.