Utility of Maternal 6-Thioguanine Nucleotide Levels in Predicting Neonatal Pancytopenia

Katsuhiko Tada; Takuzo Fujiwara; Kosuke Ota; Misao Kageyama; Hidehiko Maruyama

doi:10.1055/s-0032-1329683

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Utility of Maternal 6-Thioguanine Nucleotide Levels in Predicting Neonatal Pancytopenia

Katsuhiko Tada, Takuzo Fujiwara, Kosuke Ota, Misao Kageyama, Hidehiko Maruyama

American Journal of Perinatology Reports2012doi:10.1055/s-0032-1329683

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Abstract

An infant with pancytopenia was born to a mother who used the common immunosuppressant azathioprine (AZA). Maternal and neonatal blood levels of 6-thioguanine nucleotides (6TGN; metabolite of AZA) were 1890 and 1480 pmol/8 × 10(8) red blood cells, respectively. Maternal 6TGN levels could be useful in predicting neonatal pancytopenia.

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Authors

Katsuhiko Tada#1 Takuzo Fujiwara#2 Kosuke Ota#3 Misao Kageyama#4 Hidehiko Maruyama#5

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