Purpura Fulminans and Late Onset Group B Streptococcal Sepsis in a Premature Twin

Introduction  Purpura fulminans (PF) is a skin manifestation due to hemorrhagic infarction caused by intravascular thrombosis secondary to bacterial infections or deficiency of anticoagulants such as protein C and protein S. Neonatal PF is a rare but potentially disabling disorder associated with a high mortality and severe long term morbidity in those who survive.Case description  We report a case of a premature infant who developed extensive PF due to late onset group B streptococcus sepsis. Despite early identification and initiation of antibiotic therapy in our patient, PF progressed rapidly, leading to autoamputation of fingers and toes and severe brain injury.Conclusion  In conclusion, our case highlights the severe sequelae of PF due to late onset GBS sepsis in a premature infant.