Argyrophilic nucleolar organizer region proteins (AgNORs) as an index of clinical and radiological invasiveness in pituitary adenomas

Sixty-eight patients with pituitary adenomas were classified into groups based on their invasiveness and functional status. Mean argyrophilic nucleolar organizer region proteins (AgNOR) counts obtained from 200 cells showed no correlation with the invasive status of pituitary adenomas. However, the functional tumours showed significantly higher AgNOR counts than non-functional tumours.