Real-World Experience of Hepatitis C Treatment With Glecaprevir-Pibrentasvir During Pregnancy

L Madeline McCrary; Megan Rose Curtis; Jeannie C. Kelly; Jessica R Elrod-Gallegos; Patrick Kojima; Patricia Werner; Jennifer L. Mullersman; Tracey Habrock-Bach; Michael J. Durkin; Laura R. Marks

doi:10.1093/cid/ciag422

Enriched recordOpen access

Real-World Experience of Hepatitis C Treatment With Glecaprevir-Pibrentasvir During Pregnancy

L Madeline McCrary, Megan Rose Curtis, Jeannie C. Kelly, Jessica R Elrod-Gallegos, Patrick Kojima, Patricia Werner, Jennifer L. Mullersman, Tracey Habrock-Bach, Michael J. Durkin, Laura R. Marks

Clinical Infectious Diseases2026doi:10.1093/cid/ciag422

Citation graph

Abstract

Abstract Guidelines endorse antenatal hepatitis C virus treatment following shared decision making. No clinical trial or real-world data exist for glecaprevir-pibrentasvir (GLE/PIB). We report our experience with prenatal GLE/PIB in 14 patients. Ten patients completed treatment; all achieved virologic response by or at delivery, with no maternal or neonatal safety concerns.

Authors

L Madeline McCrary#1 Megan Rose Curtis#2 Jeannie C. Kelly#3 Jessica R Elrod-Gallegos#4 Patrick Kojima#5 Patricia Werner#6 Jennifer L. Mullersman#7 Tracey Habrock-Bach#8 Michael J. Durkin#9 Laura R. Marks

Referenced works

View all references →

No local reference links have been materialized yet.

Cited by

View all cited-by records →

Treatment of Hepatitis C During Pregnancy: We Are Approaching a “Tipping Point”

2026 · 0 citations

External reference records

Unresolved referenced work

Kept as external metadata until matched

Sofosbuvir/velpatasvir pharmacokinetics, safety, and efficacy in pregnant people with hepatitis C virus

10.1093/cid/ciae595 · 2025

Ledipasvir plus sofosbuvir in pregnant women with hepatitis C virus infection: a phase 1 pharmacokinetic study

10.1016/s2666-5247(20)30062-8 · 2020

Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection

10.1002/hep.21178 · 2006

Hepatitis C and obstetrical morbidity in a substance use disorder clinic: a role for telemedicine?

10.1016/j.ajogmf.2023.101219 · 2024

Increases in acute hepatitis C virus infection related to a growing opioid epidemic and associated injection drug use, United States, 2004 to 2014

10.2105/ajph.2017.304132 · 2018

Risk factors for perinatal transmission of hepatitis C virus

10.1097/aog.0000000000005306 · 2023

Reported prevalence of maternal hepatitis C virus infection in the United States

10.1097/aog.0000000000003644 · 2020

Society for maternal-fetal medicine consult series #56: hepatitis C in pregnancy—updated guidelines: replaces consult number 43, November 2017

Real-World Experience of Hepatitis C Treatment With Glecaprevir-Pibrentasvir During Pregnancy

Referenced works

Cited by

External reference records

Additional external references