Associations of Life’s Essential 10 with Mortality and Healthspan Free of Cardiovascular Disease and Cancer: Findings in Two Nationwide Cohorts

Abstract Aims To evaluate associations of cardiovascular health (CVH) based on Life’s Essential 10 (LE10) with all-cause mortality, cardiovascular disease (CVD) and cancer mortality and incidence, and life expectancy free of CVD and cancer. Methods and results This prospective study included 110,806 UK Biobank participants (aged 37–73) and 20,031 National Health and Nutrition Examination Survey (NHANES) participants (aged ≥20). LE10 (0–100), which integrates alcohol consumption and mental health with Life’s Essential 8, categorised CVH as low ( Conclusion Higher LE10-based CVH levels were associated with lower all-cause mortality, reduced CVD and cancer mortality and incidence, and longer life expectancy free of CVD and cancer. LE10 may provide additional targets for CVH management.