Abstract
Morowitz et al argue that the composition of enteral nutrition formulas deserves to be studied as an intervention in its own right. Building on this perspective, we consider how critical care nutrition research has progressively refined its questions from whether to feed to when and how much. We argue that enteral formula composition represents the next logical frontier in critical care nutrition research, while emphasizing the need for biologically informed, clinically meaningful, and practical interventions. We also highlight the importance of learning from previous translational challenges to ensure that future research identifies formulations that improve patient outcomes while remaining feasible for routine critical care practice.