Abstract
Background:
Despite increasing bictegravir (BIC) use during pregnancy, infant health outcomes data remain limited. We evaluated birth and growth outcomes among HIV-exposed infants (HEI) with prenatal maternal BIC exposures.
Methods:
A retrospective cohort study of HEIs with prenatal BIC exposure at Children's National Hospital during 2019–2022. Infant (birth outcomes, HIV status, and growth indicators) and maternal (demographics, viral load, and BIC use in pregnancy) data were obtained from medical records. Descriptive statistics were used to summarize infant head circumference (HC) at 0–1 month and weight-for-length (WFL) and length-for-age (LFA) at 2–3 months using mean
z
-scores overall and by duration of BIC exposure.
Results:
A total of 60 mothers (median age = 34 years [interquartile range: 26–37], 50% Black, 70% with latest HIV RNA
Conclusion:
Most HEIs with prenatal BIC exposure had favorable birth outcomes and exhibited normal early growth.