Impaired degradation of mutant α-synuclein by chaperone-mediated autophagy
10.1126/science.1101738 · doi-reference
Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome
10.1016/j.cell.2021.03.048 · doi-reference
The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane
10.1128/mcb.02070-07 · doi-reference
The coming of age of chaperone-mediated autophagy
10.1038/s41580-018-0001-6 · doi-reference
Activation of autophagy depends on Atg1/Ulk1-mediated phosphorylation and inhibition of the Hsp90 chaperone machinery
10.1016/j.celrep.2023.112807 · doi-reference
Lysosome biology in autophagy
10.1038/s41421-020-0141-7 · doi-reference
Overexpression of Atg5 in mice activates autophagy and extends lifespan
10.1038/ncomms3300 · doi-reference
Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway
10.1186/1750-1326-7-48 · doi-reference
Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila
10.4161/auto.5269 · doi-reference
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
10.1038/nature04724 · doi-reference
Loss of autophagy in the central nervous system causes neurodegeneration in mice
10.1038/nature04723 · doi-reference
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice
10.1083/jcb.200412022 · doi-reference
The role of autophagy during the early neonatal starvation period
10.1038/nature03029 · doi-reference
Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice
10.1371/journal.pgen.1000838 · doi-reference
Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease
10.1523/jneurosci.0800-08.2008 · doi-reference
Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase
10.1038/ng1884 · doi-reference
Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study
10.1093/jnen/64.2.113 · doi-reference
Age-related decline in chaperone-mediated autophagy
10.1074/jbc.m002102200 · doi-reference
The age-related accumulation of protein carbonyl in rat liver correlates with the age-related decline in liver proteolytic activities
10.1093/gerona/54.8.b318 · doi-reference
IKK phosphorylates huntingtin and targets it for degradation by the proteasome and lysosome
10.1083/jcb.200909067 · doi-reference
SUMO modification of Huntingtin and Huntington's disease pathology
10.1126/science.1092194 · doi-reference
The ubiquitin-conjugating enzyme UBE2D maintains a youthful proteome and ensures protein quality control during ageing by sustaining proteasome activity
10.1371/journal.pbio.3002998 · doi-reference
Cytoplasmic TDP-43 impairs the activity of the ubiquitin-proteasome system
10.1016/j.expneurol.2021.113833 · doi-reference
Synaptic proteasome is inhibited in Alzheimer's disease models and associates with memory impairment in mice
10.1038/s42003-023-05511-9 · doi-reference
Mutation in E1, the ubiquitin activating enzyme, reduces Drosophila lifespan and results in motor impairment
10.1371/journal.pone.0032835 · doi-reference
EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan
10.1038/emboj.2011.195 · doi-reference
Ageing and cellular maturation cause changes in ubiquitin-eye lens protein conjugates
10.1016/0003-9861(90)90006-k · doi-reference
Hyperactivation of the proteasome in Caenorhabditis elegans protects against proteotoxic stress and extends lifespan
10.1016/j.jbc.2022.102415 · doi-reference
Ageing perturbs 26S proteasome assembly in Drosophila melanogaster
10.1096/fj.06-6751com · doi-reference
Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer's-like pathology in mouse and fly APP overexpression models
10.1126/sciadv.abk2252 · doi-reference
Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during ageing or oxidative stress
10.1096/fj.12-221408 · doi-reference
Inverse correlation of protein oxidation and proteasome activity in liver and lung
10.1016/j.mad.2009.09.004 · doi-reference
Protein oxidation and degradation during postmitotic senescence
10.1016/j.freeradbiomed.2005.06.009 · doi-reference
Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation
10.1074/jbc.m301048200 · doi-reference
Proteasomal function is impaired in substantia nigra in Parkinson's disease
10.1016/s0304-3940(00)01701-8 · doi-reference
Proteasome augmentation mitigates age-related cognitive decline in mice
10.1111/acel.14492 · doi-reference
Age-associated decrease in proteasome content and activities in human dermal fibroblasts: restoration of normal level of proteasome subunits reduces ageing markers in fibroblasts from elderly persons
10.1093/gerona/62.5.490 · doi-reference
Defective ribosomal products challenge nuclear function by impairing nuclear condensate dynamics and immobilizing ubiquitin
10.15252/embj.2018101341 · doi-reference
Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions
10.1128/mcb.19.6.4535 · doi-reference
The cochaperone CHIP marks Hsp70- and Hsp90-bound substrates for degradation through a very flexible mechanism
10.1038/s41598-019-41060-0 · doi-reference
