Abstract
ABSTRACT
Context
Hypogonadism in Prader‐Willi syndrome (PWS) is associated with decreased bone mineral density (BMD) in male adolescents and adults. Testosterone Replacement Therapy (TRT) improves BMD and sexual maturation, but TRT could aggravate pre‐existing challenging behaviour in male patients with PWS.
Objective
To investigate the effect of TRT on behaviour, BMD and body composition in adolescents and young adults with PWS.
Design
Longitudinal observational study in a Dutch PWS cohort.
Participants
Fifty‐nine male patients with PWS on growth hormone treatment, aged > 14 years.
Methods
Behaviour was assessed by the Developmental Behaviour Checklist‐Parents(DBC‐P). Dual energy X‐ray absorptiometry scans were performed, measuring BMD of the lumbar spine (BMD
LS
) and total body (BMD
TB
), lean body mass (LBM) and fat mass percentage (FM%).
Results
59 patients with a median (IQR) age of 22.57 (18.46–26.35) years, of which 44 used TRT. Median age at TRT initiation was 16.6 years. Three patients (6.8%) discontinued TRT permanently due to challenging behaviour. In 30 patients (68.2%), there was no behaviour necessitating a dose change or discontinuation. DBC‐P total score did not significantly change during TRT. BMD SDS stabilised following TRT initiation, with a mean (95% CI) BMD SDS difference from baseline of 0.24 (−0.06 to 0.54;
p
= 0.107) BMD
LS
and −0.28 (−0.50 to −0.06;
p
= 0.014) BMD
TB
after 5 years. LBM SDS improved and FM% SDS remained similar.
Conclusion
Under close surveillance, TRT is an efficacious method to maintain BMD and improve body composition in hypogonadal male patients with PWS, with minor effects on behaviour in most cases.