Younger Age Is Associated With Slower PSA Decline After Low‐Dose‐Rate Brachytherapy for Localized Prostate Cancer

ABSTRACT Objectives To evaluate the association of age with PSA kinetics and biochemical control after low‐dose‐rate brachytherapy (LDR‐BT). Methods We retrospectively analyzed 347 patients treated with LDR‐BT alone without androgen deprivation therapy between 2004 and 2015. Longitudinal PSA changes were evaluated using linear mixed‐effects models with natural cubic splines for time. Age was modeled as a continuous fixed effect, including interactions with the spline terms for time. Time to PSA nadir Results Younger age was significantly associated with slower PSA decline over 5 years ( p  p   Conclusions Age was significantly associated with PSA kinetics following LDR‐BT, with younger patients showing slower PSA decline and a delayed achievement of PSA nadir < 0.2 ng/mL. However, these age‐related differences were not associated with biochemical recurrence.