Abstract
ABSTRACT
Pyoderma gangrenosum (PG) is a rare chronic neutrophilic dermatosis closely associated with immune dysregulation and characterized by painful, treatment‐resistant ulcers. Currently, no standardized therapeutic protocol exists; however, topical and systemic immune‐modulating therapies have shown positive results. In this article, we evaluate the use of polylactic acid (PLA) matrices as a treatment option, given their immunomodulatory properties and beneficial effects on complex wounds. This case series presents six patients (ages 38–72, five female and one male) with chronic, non‐healing ulcers that persisted for 6 months to 3 years previous to the treatment described. PLA matrices were used as the primary wound treatment, requiring a mean of 5.3 applications for healing. Wound closure was achieved in all cases within a mean time of 13.4 weeks with successful outcomes in both scar quality and appearance. PLA matrices may represent a promising local treatment option for PG ulcers; however, these preliminary findings require confirmation in larger, controlled studies.