Abstract
ABSTRACT
Introduction
Neotropical primates (NTPs) present varying susceptibility to toxoplasmosis caused by
Toxoplasma gondii
, but their immunopathogenic responses remain poorly understood.
Materials and Methods
Local immune responses were characterized in the liver, spleen, and central nervous system (CNS) of 50 naturally infected NTPs (31
Callithrix
spp.; 19
Alouatta
spp.) by immunohistochemistry. Splenic white pulp morphometry, CD3+ T lymphocyte, Iba1+ macrophage/microglia, polymorphonuclear neutrophil quantification, and IFN‐γ and IL‐10 semi‐quantification were performed.
Results
Both genera exhibited splenic white pulp hyperplasia. Within genera, marmosets showed predominant CD3+ infiltrates in the spleen and histiocytic infiltrates in the liver and CNS, whereas howler monkeys exhibited predominantly histiocytic infiltrates in all tissues. Between genera, marmosets had significantly higher splenic CD3+ T‐cell (
p
p
= 0.030), and IFN‐γ (
p
= 0.018) immunolabeling than howler monkeys.