Abstract
ABSTRACT
Gestational choriocarcinoma with inferior vena cava (IVC) tumor thrombus formation is exceedingly rare. We report a case initially presenting with recurrent nausea and vomiting in a 52‐year‐old woman. Laboratory studies revealed elevated serum β‐hCG levels, and ultrasonography demonstrated a pelvic mass extending from the parametrial area into the IVC. Pathological examination of a pelvic mass biopsy confirmed the diagnosis of choriocarcinoma. Further assessment identified pulmonary hypertension and emboli within small pulmonary artery branches. The patient received EMA‐CO chemotherapy and achieved complete remission, with no evidence of recurrence during a one‐year follow‐up. This case highlights the diagnostic challenges posed by non‐classical metastases and underscores the importance of considering choriocarcinoma in the differential diagnosis of women with a pregnancy history and unexplained systemic symptoms.