A Case of Primary Intramedullary Infantile Fibrosarcoma With an RBPMS::NTRK3 Fusion and Response to Larotrectinib

Mégane Le Quang; Julie Tandonnet; Nathalène Truffaux; Lucile Vanhersecke; Jean Delmas; Arthur Durouchoux; Dorian Bochaton; Arnault Tauziède‐Espariat; Guillaume Chotard

doi:10.1111/nan.70102

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A Case of Primary Intramedullary Infantile Fibrosarcoma With an RBPMS::NTRK3 Fusion and Response to Larotrectinib

Mégane Le Quang, Julie Tandonnet, Nathalène Truffaux, Lucile Vanhersecke, Jean Delmas, Arthur Durouchoux, Dorian Bochaton, Arnault Tauziède‐Espariat, Guillaume Chotard

Neuropathology and Applied Neurobiology2026doi:10.1111/nan.70102

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Abstract

Summary First reported case of primary central nervous system infantile fibrosarcoma. Expansion of the molecular spectrum of infantile fibrosarcoma with identification of an RBPMS::NTRK3 fusion. Marked efficacy of larotrectinib observed in an unresectable CNS tumour. Reinforces the importance of molecular testing in atypical paediatric CNS tumours.

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Mégane Le Quang#1 Julie Tandonnet#2 Nathalène Truffaux#3 Lucile Vanhersecke#4 Jean Delmas#5 Arthur Durouchoux#6 Dorian Bochaton#7 Arnault Tauziède‐Espariat#8 Guillaume Chotard#9

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2020

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A Case of Primary Intramedullary Infantile Fibrosarcoma With an RBPMS::NTRK3 Fusion and Response to Larotrectinib

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