Abstract
ABSTRACT
Background
Conventional treatments for common and plantar warts often have limited efficacy and high recurrence rates. 5‐Aminolevulinic acid photodynamic therapy (5‐ALA‐PDT) has attracted increasing attention as an alternative therapeutic option for these lesions. This study investigated the potential of 5‐ALA‐PDT as an alternative treatment option for patients with refractory common and plantar warts.
Objective
To explore the clinical efficacy of 5‐ALA‐PDT and recombinant human interferon alpha 2b (rhIFN‐α2b) spray combination therapy against common and plantar warts.
Methods
We enrolled 104 patients with common or plantar warts and randomly assigned them to the intervention (5‐ALA‐PDT combined with rhIFN‐α2b spray;
n
= 51) or control (cryotherapy;
n
= 53) group to compare treatment efficacy, recurrence rate, and adverse events.
Results
After three consecutive treatment cycles, the 4‐week complete recovery and total effective rates were 90.20% and 96.08% in the intervention group, versus 62.26% (
p
= 0.002) and 77.36% (
p
= 0.013) in the control group. Recurrence rates were significantly lower in the intervention group at 8 weeks (2.17% vs. 24.24%), 12 weeks (4.35% vs. 33.33%), and 6 months (4.35% vs. 39.39%; all
p
Conclusion
5‐ALA‐PDT combined with rhIFN‐α2b spray exhibited superior clinical efficacy in treating common and plantar warts, significantly improving treatment efficacy, reducing medium‐term recurrence, and demonstrating good safety and tolerability.